哮喘联盟

   摘要
   背景：戒烟可降低心血管疾病的发病率，并且可以改善公众健康。本项目旨在研究戒烟对高密度脂蛋白（HDL）功能的影响。
   方法和结果：我们随机地对32名吸烟者给予为期12周的戒烟治疗（VN-SEESAW研究，给予伐尼克兰或尼古丁贴剂治疗）。在戒烟疗法进行前后分别进行毛细管等速电泳（分析血脂情况、血浆及高密度脂蛋白中的丙二醛（MDA）水平、高密度脂蛋白亚组分情况）、胆固醇外流能力检测以及高密度脂蛋白的抗炎活性检测。结果显示，戒烟治疗后，HDL-C、apoA-I水平及高密度脂蛋白亚组分等指标与戒烟前测量数据相比并没有发生明显的变化。但是，胆固醇外流能力及高密度脂蛋白炎症指数（HII）得到了明显的改善。以上两项指标的变化（%∆胆固醇外流能力及∆HII）在戒烟成功组及戒烟失败组之间也存在显著的差异，成功组显著高于失败组。此外，胆固醇外流能力及HII的变化还与呼气后CO浓度及高密度脂蛋白中的丙二醛水平相关。
   结论：本研究的结果表明，戒烟可提高高密度脂蛋白的功能，提高胆固醇外流能力，并且降低高密度脂蛋白炎症指数，而戒烟前后HDL-C、apoA-I水平、高密度脂蛋白亚组分等并没有发生明显变化。这可能是戒烟降低心血管疾病发病率的机制之一。
 

（刘国梁 审校）
Circ J. 2014 Oct 16. [Epub ahead of print]

 

Impact of Cigarette Smoking Cessation on High-Density Lipoprotein Functionality.
 

Takata K1, Imaizumi S, Kawachi E, Suematsu Y, Shimizu T, Abe S, Matsuo Y, Tsukahara
H, Noda K, Yahiro E, Zhang B, Uehara Y, Miura SI, Saku K.
 

ABSTRACT
BACKGROUND:Smoking cessation reduces the risk of cardiovascular disease (CVD) and improves clinical outcomes in public health. We studied the effect of smoking cessation on high-density lipoprotein (HDL) functionality.
METHODS AND RESULTS:We randomly treated 32 smokers with varenicline or a transdermal nicotine patch as part of a 12-week smoking cessation program (The VN-SEESAW Study). The plasma lipid profiles, plasma and HDL malondialdehyde (MDA) levels, HDL subfractions as analyzed by capillary isotachophoresis, cholesterol efflux capacity, and antiinflammatory activity of HDL were measured before and after the anti-smoking intervention. After smoking cessation, HDL-C, apoA-I levels and HDL subfractions were not significantly different from the respective baseline values. However, cholesterol efflux capacity and the HDL inflammatory index (HII) were significantly improved after smoking cessation. The changes in both parameters (%∆ cholesterol efflux capacity and ∆HII) were also significantly improved in the successful smoking cessation group compared with the unsuccessful group. The changes in cholesterol efflux capacity and HII also correlated with those in end-expiratory CO concentration and MDA in HDL, respectively.
CONCLUSIONS:Our findings indicate that smoking cessation leads to improved HDL functionality, increased cholesterol efflux capacity and decreased HII, without changing HDL-C or apoA-I levels or HDL subfractions. This may be one of the mechanisms by which smoking cessation improves the risk of CVD.
 

Circ J. 2014 Oct 16. [Epub ahead of print]