哮喘联盟

   摘要
   背景：哮喘、喉炎和慢性咳嗽是胃食管反流病的非典型性症状。
   目标：分析腹腔镜手术在缓解胃食管反流病患者的与哮喘相关的食管外症状方面的效果。
   方法：对1994年-2006年的400例接受腹腔镜胃底折叠术的胃食管反流病患者的医疗记录进行了查阅，找出了30例存在与哮喘相关的食管外症状的患者。考虑的变量有:性别、年龄、胃食管症状(烧心、反酸和吞咽困难)、胃食管反流病的时间、质子泵抑制剂的治疗、特殊药物的使用、治疗和进展、症状发作的次数及食管炎的程度。对术前和术后的资料进行统计学分析。
   结果：术前(T1)和术后6个月(T2)的对比分析显示：术后的烧心和反流症状明显较少。除此以外，哮喘的日常发作风险(T1 vs T2, 45.83% to 16.67%, p=0.0002)和持续性风险(T1, 41.67% vs T2, 8.33%, p=0.0002)存在显著差异。
   结论：腹腔镜胃底折叠术在改善反流病的典型症状和哮喘的临床症状方面有显著效果。
 

（林江涛 审校）
Arq Bras Cir Dig. 2014 Sep;27(2):92-5.

 

Laparoscopic antireflux surgery in patients with extra esophageal symptoms related to asthma.
 

[Article in English, Portuguese]
Silva AP, Tercioti-Junior V, Lopes LR, Coelho-Neto Jde S, Bertanha L, Rodrigues PR, Andreollo NA.
 

ABSTRACT
BACKGROUND: Asthma, laryngitis and chronic cough are atypical symptoms of the gastroesophageal reflux disease.
AIM: To analyze the efficacy of laparoscopic surgery in the remission of extra-esophageal symptoms in patients with gastroesophageal reflux, related to asthma.
METHODS: Were reviewed the medical records of 400 patients with gastroesophageal reflux disease submitted to laparoscopic Nissen fundoplication from 1994 to 2006, and identified 30 patients with extra-esophageal symptoms related to asthma. The variables considered were: gender, age, gastroesophageal symptoms (heartburn, acid reflux and dysphagia), time of reflux disease, treatment with proton pump inhibitor, use of specific medications, treatment and evolution, number of attacks and degree of esophagitis. Data were subjected to statistical analysis, comparing the pre- and post-surgical findings.
RESULTS: The comparative analysis before surgery (T1) and six months after surgery (T2) showed a significant reduction on heartburn and reflux symptoms. Apart from that, there was a significant difference between the patients with daily crises of asthma (T1 versus T2, 45.83% to 16.67%, p=0.0002) and continuous crises (T1, 41.67% versus T2, 8.33%, p=0.0002).
CONCLUSION: Laparoscopic Nissen fundoplication was effective in improving symptoms that are typical of reflux disease and clinical manifestations of asthma.
 

Arq Bras Cir Dig. 2014 Sep;27(2):92-5.