哮喘联盟

   摘要
   生活质量(QoL)的评估已经成为评估慢性疾病（如哮喘）对患者日常生活的影响的最重要的标准之一，对成年人和儿童都是如此。此项开放性观察研究的目的是评估哮喘儿童的生活质量及分析生活质量的潜在性影响因素（如症状和功能性呼吸参数）。127例6-14岁的罗马门诊哮喘患儿参与了此项研究。他们接受了皮肤点刺试验（SPT）和肺功能测定，填写了儿童生活质量调查问卷（PAQLQ）。111例被诊断为间歇性哮喘，12例被诊断位轻度哮喘，4例被诊断为中度持续性哮喘。96例儿童SPT试验阳性。调查问卷评估结果显示QoL的总体平均得分是5.4。基于QoL评分将患儿分为2组：较低QoL评分组（QoL评分<5.5），较高QoL评分组（QoL评分>5.5）。与较低QoL评分组的儿童相比，较高QoL评分组的儿童及其母亲的平均年龄较大，在该研究前一年内的哮喘发作较少，FEV1的平均值较高。逻辑回归分析显示：QoL的主要影响因素有FEV1、前一年的哮喘症状及患儿母亲的年龄。QoL与哮喘的发作频率和FEV1值相关。另外，本项研究也显示：正常肺功能的患者可能也存在QoL的严重受损。这表明了QoL评估在所有哮喘患儿中的重要性。
 

（林江涛 审校）
Int J Immunopathol Pharmacol. 2014 Jul-Sep;27(2):235-44.

 

Risk factors affecting quality of life in a group of italian children with asthma.
 

Indinnimeo L1, Chiarotti F2, De Vittori V1, Baldini L3, De Castro G1, Zicari AM1, Tancredi G1, Leonardi L1, Duse M1.
 

ABSTRACT
The measure of Quality of Life (QoL) has become one of the most important criteria used to assess the impact of chronic illness, such as asthma, on the patient’s daily life, in adults and children alike. The objective of our open observational study was to measure the QoL and analyze several factors that potentially affect QoL, such as symptoms and functional respiratory parameters, in a cohort of children with asthma. One hundred and twenty-seven children with asthma, 6 to 14 years of age, living in the city of Rome, were enrolled as outpatients. They were subjected to Skin Prick Tests (SPT), underwent spirometry and filled out the Pediatric Asthma Quality of Life Questionnaire (PAQLQ). One hundred and eleven children were diagnosed with intermittent asthma, 12 (10&#x0025;) with mild asthma, and four with moderate persistent asthma. Ninety-six children had a positive SPT. The mean total score of QoL, obtained from the questionnaire, was 5.4 (&#x2213;1.2 SD). Two QoL groups were created. Children with total QoL score <5.5 were included in the “Lower QoL” score group while children with total QoL score &#8805; 5.5 were included in the “Higher QoL” score group. Children in the Higher group and their mothers had a higher mean age, suffered from fewer asthma exacerbations during the year preceding the study, and showed a higher mean value of forced expiratory volume (FEV1) compared to the children in the Lower category. Using Logistic regression we identified the main factors that may affect QoL as FEV1, symptoms in the previous year and mother’s age. QoL is correlated with the frequency of asthma exacerbations and FEV1 values. Furthermore, our research shows that a significant impairment of QoL may also occur in patients with normal lung function, pointing out the importance of evaluating QoL in all children with asthma.
 

Int J Immunopathol Pharmacol. 2014 Jul-Sep;27(2):235-44.