胎次、初产年龄与哮喘死亡风险:一项台湾队列研究的证据

2014/08/11

   摘要
   本研究旨在探讨初产年龄、胎次和哮喘死亡风险之间是否存在关联。研究纳入1292462例在1978年1月1日-1987年12月31日期间首次生育的台湾女性。研究对每一例女性自第一次分娩之日起至2009年12月31日进行跟踪,通过与电脑程序化的死亡率数据库的记录进行链接,确定她们的生命状态。研究使用Cox比例风险回归模型估计哮喘死亡的风险比与胎次和初产年龄的关系。哮喘死亡风险随着初产年龄的增加呈上升趋势。与只有一个活产胎儿女性相比,有两个活产胎儿女性的调整后的危险比为0.75(95%可信区间(CI)=0.53-1.08),那些具有三个或更多胎儿女性的危险比为0.53(95%CI=0.36-0.78)。随着胎次的增加,哮喘死亡的调整风险比呈显著下降趋势。此项研究是首次为支持生殖因素(胎生和早期初产年龄)和哮喘死亡风险之间存在关联提供证据的研究。

 

(苏楠 审校)
Int J Environ Res Public Health. 2014 Jun 11;11(6):6147-6155.


 

 

Parity, Age at First Birth, and Risk of Death from Asthma: Evidence from a Cohort in Taiwan.
 

Chen CC1, Chiu HF2, Yang CY3.
 

ABSTRACT
This study was undertaken to examine whether there is an association between age at first birth and parity and risk of asthma death. The study cohort consisted of 1,292,462 women in Taiwan who had a first live birth between 1 January 1978 and 31 December 1987. We tracked each woman from the date of their first childbirth to 31 December 2009, and their vital status was ascertained by linking records with the computerized mortality database. Cox proportional hazard regression models were used to estimate hazard ratios of death from asthma associated with parity and age at first birth. A trend of increasing risk of asthma death was seen with increasing age at first birth. The adjusted hazard ratio was 0.75 (95% confidence interval (CI) = 0.53-1.08) among women with two live births and 0.53 (95% CI = 0.36-0.78) among those with three or more births, compared with women who had one live birth. There was a significant decreasing trend in adjusted hazard ratios of asthma death with increasing parity. This study is the first to provide evidences to support an association between reproductive factors (parity and early age at first birth) and the risk of asthma death.

 

Int J Environ Res Public Health. 2014 Jun 11;11(6):6147-6155.


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