哮喘联盟

   摘要
   背景：以往关于运动干预对戒烟作用的研究存在一些方法学局限，从而混淆了有氧运动对戒烟的潜在作用。
   方法：采用随机对照试验（RCT）研究行为运动干预对戒烟的初步疗效，并纳入了可用以排除以往方法学局限性的相关特征。61例吸烟者（65.6%为女性，平均年龄47.3岁，平均抽19.7支/天）被随机分为两组：一组接受12周的运动干预，另一组接受12周的健康教育（对照组）。两组受试者均接受为期8周的、电话形式的标准戒烟方案（包括使用经皮尼古丁贴片）。分别在治疗结束时（EOT）、6个月和12个月进行随访。
   结果：两组受试者每周参与运动和健康教育的次数无明显差异（分别为9.3±2.8 vs. 9.3±3.0）。虽然未达到统计学意义，但运动干预组的确诊戒烟率更高（EOT: 40% vs. 22.6%，优势比OR= 2.28；6个月及12个月的随访结果：26.7% vs. 12.9%，优势比OR=2.46）。无论治疗情况如何，中高度运动与干预期抑郁症状降低有关。
   结论：本项小样本RCT研究结果显示了行为运动干预对戒烟的有益影响，旨在解决以往研究方法学上的局限性。鉴于运动干预利于戒烟这个结论的潜在公众健康影响，我们应该通过更大型的RCTs对戒烟运动干预进行继续发展和优化。
 

（刘国梁 审校）
Nicotine Tob Res. 2014 May 8. [Epub ahead of print]

 

A Preliminary Randomized Controlled Trial of a Behavioral Exercise Intervention for Smoking Cessation.
 

Abrantes AM1, Bloom EL, Strong DR, Riebe D, Marcus BH, Desaulniers J, Fokas K, Brown RA.
 

ABSTRACT
INTRODUCTION: Previous exercise intervention studies for smoking cessation have been challenged by a number of methodological limitations that confound the potential efficacy of aerobic exercise for smoking cessation.
METHODS: The preliminary efficacy of a behavioral exercise intervention that incorporated features designed to address prior limitations was tested in a randomized controlled trial (RCT). Sixty-one smokers (65.6% female, mean age = 47.3 years; smoked a mean of 19.7 cigarettes/day) were randomized to receive either a 12-week exercise intervention OR a 12-week health education contact control. Participants in both conditions received an 8-week telephone-delivered, standard smoking cessation protocol (with the transdermal nicotine patch). Follow-ups were conducted at the end of treatment (EOT), 6- and 12-month timepoints.
RESULTS: There were no differences between conditions with respect to the number of weekly exercise or health education sessions attended (9.3±2.8 vs. 9.3±3.0, respectively). While not statistically significant, participants in the exercise condition demonstrated higher verified abstinence rates (EOT: 40% vs. 22.6%, odds ratio [OR] = 2.28; 6- and 12-month follow-ups: 26.7% vs. 12.9%, OR = 2.46). Irrespective of treatment condition, higher levels of moderate-to-vigorous exercise were associated with lower levels of depressive symptoms during the intervention.
CONCLUSIONS: The results of this small RCT point toward the benefit of a behavioral exercise intervention, designed to address previous methodological limitations, for smoking cessation. Given the potential public health impact of the demonstrated efficacy of exercise for smoking cessation, the continued development and optimization of exercise interventions for smokers through larger RCTs merits pursuit.
 

Nicotine Tob Res. 2014 May 8. [Epub ahead of print]