哮喘联盟

   摘要
   本研究的目的是总结和分析那些支持使用ω-3脂肪酸治疗和预防儿童哮喘研究的结果，鉴于近期遗传证据，ω-3治疗和预防儿童哮喘的作用体现在哮喘发病过程中的作用，这些研究结果对今后研究的意义也在文中进行了探讨。虽然有相当数量在儿童中进行的观察性研究显示膳食摄入ω-3脂肪酸对儿童哮喘的有益作用，然而仍然缺乏完整、充分设计并严格进行的调查研究。此外，在哮喘儿童中进行的与ω-3脂肪酸补充剂相关的仅有的几个介入试验经常产生矛盾的结果。伴随哮喘产生的遗传多态性与基因营养的相互作用是未被考虑的因素，也许可以解释为何这些干预试验出现不一致的结果。因此，为深入探讨长链多不饱和脂肪酸对哮喘的影响，未来的研究应包括对关键基因变异的分析。虽然还不能确切的得出补充ω-3脂肪酸对预防儿童哮喘或修饰哮喘疾病的有益作用的结论，但尚有足够的证据来支持这种可能性。因此，未来显然需要对饮食方法减少哮喘的可能发展和/或成功治疗哮喘疾病的可行性进行研究。从公共健康的角度来看，如果饮食的方法被成功地证明有效，即使只有一个队列的易感个体，它将提供比当前可用的更好的管理工具，具有更好的耐受性，从长远来看，更符合成本效益。
 

（苏楠 审校）
Allergy Asthma Proc. 2014 May;35(3):233-40. doi: 10.2500/aap.2014.35.3736.

 

Omega-3 fatty acids and asthma in children.
 

D'Auria E1, Miraglia Del Giudice M, Barberi S, Mandelli M, Verduci E, Leonardi S, Riva E, Giovannini M.
 

ABSTRACT
The purpose of this study was to summarize and analyze the results of studies supporting the use of omega-3 fatty acids for their therapeutic and preventive value in childhood asthma in light of recent genetic evidence strongly suggesting a pathogenetic role in asthma and to discuss the implications of these findings for future research. Although a considerable number of observational studies have been conducted in children showing a beneficial effect of omega-3 dietary intake in asthma, a fully well-designed, rigorously conducted investigational study is still lacking. Additionally, the few interventional trials with omega-3 supplementation conducted in asthmatic children have often yielded conflicting results. The genetic polymorphism and the gene-nutritional interactions that accompany asthma can be the missing factors and may explain the inconsistent results found in these interventional trials. Therefore, the analyses of key genes variants should be included in future studies to thoroughly investigate the effects of long-chain polyunsaturated fatty acid on asthma. Although a definitive conclusion can not be made supporting a beneficial effect of dietary modification or supplementation with omega-3 for the prevention or modification of asthmatic disease in children, there is sufficient evidence to support this possibility. There is, therefore, a clear need for future research to investigate the feasibility of this dietetic approach to reduce the likely development of asthma and/or the successful treatment of asthmatic disease. From a public health perspective, if a dietetic approach is successfully documented, even if only in a cohort of susceptible individuals, it would offer a far better management tool than currently available, better tolerated, and, in the long run, more cost-effective.
 

Allergy Asthma Proc. 2014 May;35(3):233-40. doi: 10.2500/aap.2014.35.3736.