脂肪酸、炎症和哮喘
2014/05/07
摘要
脂肪酸及其相关膳食在炎症介质的形成中起着至关重要的作用，后者参与哮喘的发病机制。由于ω-6（n-6）和ω-3（n-3）脂肪酸摄入量的改变最终决定细胞膜的功能，因此膳食的改变可能对这类脂肪酸衍生的炎症介质下游产物具有潜在调节作用。长期以来人们推测降低n-6/n-3比例能减少促炎症介质更多的产生，而增加下游代谢产物的生成能限制或缓解炎症。换言之，这些变化将改善哮喘结局或降低哮喘的发生风险。本综述将重点介绍脂肪酸的抗炎作用，以及膳食和肥胖如何改变脂肪酸特征进而导致哮喘的临床和流行病学数据。
（苏楠 审校）
JAllergyClinImmunol.2014Mar7.pii:S0091-6749(14)00086-4.doi:10.1016/j.jaci.2013.12.1087. [Epub ahead of print]
Fatty acids, inflammation, and asthma.
Wendell SG1, Baffi C1, Holguin F2.
Abstract
Fatty acids and consequently diet play an essential role in the formation of inflammatory mediators involved in the pathogenesis of asthma. Because intake variations of omega-6 (n-6) and omega-3 (n-3) fatty acids ultimately determine cell membrane incorporation, changes in diet have the potential to modify downstream production of inflammatory mediators derived from these compounds. It has long been hypothesized that decreasing the n-6/n-3 ratio could reduce the production of more proinflammatory mediators while increasing the formation of downstream metabolites that can serve to limit or resolve inflammation. In turn, these changes would result in improved asthma outcomes or would lower the risk for asthma incidence. This review will focus on the role of fatty acid inflammatory and resolving mediators and will summarize the clinical and epidemiologic data on how diet and obesity alter fatty acid profiles that can contribute to asthma.
JAllergyClinImmunol.2014Mar7.pii:S0091-6749(14)00086-4.doi:10.1016/j.jaci.2013.12.1087. [Epub ahead of print]
