哮喘联盟

   摘要
   背景：孕期母亲饮食可能影响儿童过敏和哮喘。
   目的：旨在研究母亲在早期妊娠摄入儿童常见食物过敏原与儿童过敏和哮喘的关系。
   方法：我们研究了1277对来自美国prebirth 队列中的母子（未筛选任何疾病）。在妊娠早期和中期使用食物频率问卷评估孕期母亲摄入的常见儿童食物过敏原。在儿童中期（平均年龄7.9岁），通过调查问卷和血清特异性IgE水平评估食物过敏、哮喘、过敏性鼻炎和过敏性皮炎。我们研究了妊娠期母亲饮食和儿童过敏与哮喘的关系。同时也研究了特定食物、哮喘和儿童中期过敏状态的横断面关系。
   结果：在儿童中期，食物过敏常见（5.6%），表现为至少对1种食物过敏原敏感（28%）。妊娠早期母亲花生摄入更多（每额外增加分值）与花生过敏反应减少47%有关（优势比 [OR]，0.53；95% CI，0.30-0.94）。妊娠早期牛奶摄入更多与哮喘（OR, 0.83; 95% CI, 0.69-0.990和过敏性鼻炎(OR, 0.85; 95% CI, 0.74-0.97)减少有关。妊娠中期小麦摄入更多与过敏性皮炎减少有关（OR, 0.64; 95% CI, 0.46-0.90）。花生、小麦和大豆过敏均与儿童哮喘、过敏性皮炎和过敏性鼻炎增加成横断面相关（ORs, 3.6 - 8.1）。
   结论：妊娠早期母亲摄入更多的花生、牛奶和小麦与儿童中期过敏和哮喘几率减少有关。
 

（林江涛 审校）
J Allergy Clin Immunol. 2014Feb9.pii:S0091-6749(13)02989-8. doi:10.1016/j.jaci. 2013. 11.040.[Epub ahead of print]


 

Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children.
 

Bunyavanich S1, Rifas-Shiman SL2, Platts-Mills TA3, Workman L3, Sordillo JE4, Camargo CA Jr5, Gillman MW2, Gold DR6, Litonjua AA6.
 

Abstract
BACKGROUND: Maternal diet during pregnancy may affect childhood allergy and asthma.
OBJECTIVE: We sought to examine the associations between maternal intake of common childhood food allergens during early pregnancy and childhood allergy and asthma.
METHODS: We studied 1277 mother-child pairs from a US prebirth cohort unselected for any disease. Using food frequency questionnaires administered during the first and second trimesters, we assessed maternal intake of common childhood food allergens during pregnancy. In mid-childhood (mean age, 7.9 years), we assessed food allergy, asthma, allergic rhinitis, and atopic dermatitis by questionnaire and serum-specific IgE levels. We examined the associations between maternal diet during pregnancy and childhood allergy and asthma. We also examined the cross-sectional associations between specific food allergies, asthma, and atopic conditions in mid-childhood.
RESULTS: Food allergy was common (5.6%) in mid-childhood, as was sensitization to at least 1 food allergen (28.0%). Higher maternal peanut intake (each additional z score) during the first trimester was associated with 47% reduced odds of peanut allergic reaction (odds ratio [OR], 0.53; 95% CI, 0.30-0.94). Higher milk intake during the first trimester was associated with reduced asthma (OR, 0.83; 95% CI, 0.69-0.99) and allergic rhinitis (OR, 0.85; 95% CI, 0.74-0.97). Higher maternal wheat intake during the second trimester was associated with reduced atopic dermatitis (OR, 0.64; 95% CI, 0.46-0.90). Peanut, wheat, and soy allergy were each cross-sectionally associated with increased childhood asthma, atopic dermatitis, and allergic rhinitis (ORs, 3.6 to 8.1).
CONCLUSION: Higher maternal intake of peanut, milk, and wheat during early pregnancy was associated with reduced odds of mid-childhood allergy and asthma.
 

J Allergy Clin Immunol. 2014Feb9.pii:S0091-6749(13)02989-8. doi:10.1016/j.jaci. 2013. 11.040.[Epub ahead of print]