哮喘联盟

   摘要
   目的：旨在确定门诊诊断的哮喘患者的肥胖发病率，研究其与哮喘严重性和控制程度的关系。
   方法：一项横断面研究中，从巴西卡尼斯阿雷格里港医院的哮喘门诊中，纳入年龄≥11岁的确诊的哮喘患者，所有受试者均接受常规问卷调查（哮喘控制问卷）和肺功能检测。通过体重指数（BMI）进行营养状况分类。
   结果：该研究共纳入272例患者，平均年龄为51.1 ± 16.5，其中206例（74.9%）为女性患者。平均BMI为 27.5 ± 5.3kg/m(2)，96例（35.3%）为正常体重，97例（35.7%）超重。79例（29%）肥胖。在肥胖组中，女性的比率显著增加（34.3% vs. 13.2%， P = 0.002）。而哮喘控制（P=0.741）和严重程度（P=0.506）没有显著差异。在肥胖组中，FEV1%的预测值与非肥胖组相比，显著增加（73.7% vs. 67.2%，P= 0.037）。逻辑回归分析证明，性别是哮喘肥胖的独立预测因素（OR = 3.84，P = 0.002）。
   结论：该研究表明，哮喘患者肥胖的发病率高。而在肥胖和非肥胖受试者中，哮喘严重程度和控制水平相似。在哮喘患者中，女性与肥胖相关。
 

（苏楠 审校）
RevAssocMedBras.2013Oct30.pii:S0104-4230(13)00178-4.doi:10.1016/j.ramb.2013.06.015. [Epub ahead of print]


 

Prevalence of obesity in asthma and its relations with asthma severity and
control.
 

Forte GC, Grutcki DM, Menegotto SM, Pereira RP, Dalcin PD.
 

Abstract
OBJECTIVE: To determine the prevalence of obesity in asthmatic patients attending at an outpatient clinic, and to investigate its relationships with asthma severity and level of asthma control.
METHODS: In a cross-sectional study we recruited patients aged 11 years and older with confirmed asthma diagnosis from the outpatient asthma clinic of Hospital de Clínicas de Porto Alegre, Brazil. They underwent an evaluation by a general questionnaire, an asthma control questionnaire and by pulmonary function tests. Nutritional status was classified by body mass index (BMI).
RESULTS: 272 patients were included in the study. Mean age was 51.1 ± 16.5 years and there were 206 (74.9%) female patients. Mean BMI was 27.5 ± 5.3kg/m2, and 96 (35.3%) patients were classified as normal weight, 97 (35.7%) as overweight and 79 (29%) as obesity. There was a significant higher proportion of female than male patients (34.3% vs. 13.2%, p = 0.002) in the obesity group. There were no significant differences with respect to asthma control (p = 0.741) and severity classification (p = 0.506). The FEV1% predicted was significantly higher in the obese than in the non-obese group (73.7% vs. 67.2%, p = 0.037). Logistic regression analysis identified sex (OR = 3.84, p = 0.002) as an independent factor associated with obesity.
CONCLUSIONS: This study showed a high prevalence of obesity in asthmatic patients. Obese and non-obese subjects were similar in regard to asthma severity and level of asthma control. Female sex was associated with obesity in this asthma population.
 

RevAssocMedBras.2013Oct30.pii:S0104-4230(13)00178-4.doi:10.1016/j.ramb.2013.06.015. [Epub ahead of print]