成年起病的哮喘与特定心血管疾病的相关性分析
2013/12/09
研究背景：哮喘经常与心血管疾病伴随发生，但其与心血管疾病特定症状的具体关系尚无详细描述。
研究对象和方法：该研究回顾性分析了美国16,493例18～90岁同时具有哮喘和心血管疾病症状的成年患者资料。研究采用横断面分析方法对1999～2006国家健康与营养检测调查结果进行统计分析。研究采用多因素logistic回归的分析方法，在采用年龄、性别和其他心血管疾病危险因素进行校正的基础上，分析心血管疾病危险因素的流行病学趋势和发生率。
结果：哮喘的幼年发病率和成年发病率分别为4.8%何3.3%。成年发病的哮喘患者与总的心血管疾病事件具有很显著地相关性(ORZ2.07, CIZ1.2-3.7)，而幼年发病的哮喘患者与心血管疾病不具备统计学上的相关性。在四种心血管疾病事件研究终点中，成年发病的哮喘患者主要与冠心病有显著地相关性(ORZ2.26, CIZ1.2-4.2)。
结论：以上研究表明冠心病是与支气管哮喘伴随发生的主要心血管疾病事件，但该结论仍然需要更多前瞻性的研究来证实。
（方萍 西安交通大学医学院第二附属医院 710004 摘译）
（Respir Med. 2012 Jul;106(7):948-53. doi: 10.1016/j.rmed.2012.02.017. Epub 2012 Mar 24.）
Association of adult-onset asthma with specific cardiovascular conditions
Lee HM, Truong ST, Wong ND.
Heart Disease Prevention Program, Division of Cardiology, Department of Medicine, School of Medicine, 112 Sprague Hall, University of California, Irvine, CA 92697-4101, USA.
Abstract
BACKGROUND: While asthma is known to be associated with cardiovascular disease (CVD), the relation to specific manifestations of CVD has not been previously described. Our objective was to explore the relation of child and adult-onset asthma with specific CVD conditions.
METHODS: We examined data from 16,943 (projected 178 million) U.S. adults aged 18e90 years old with relevant information on asthma and CVD. The study was a cross-sectional analysis of the National Health and Nutrition Examination Survey 1999e2006. We determined the preva- lence of CVD risk factors and likelihood of CVD conditions according to gender and asthma status using multiple logistic regression adjusted for age, gender and other CVD risk factors.
RESULTS: The proportions of subjects with child and adult-onset asthma were 4.8% (nZ702) and 3.3% (nZ534), respectively. Adult-onset asthma was significantly associated with total CVD (ORZ2.07, CIZ1.2e3.7), but child-onset asthma was not associated with any CVD condi-tions. Of the four specific CVD endpoints, adult-onset asthma overall was only associated with coronary heart disease (CHD) (ORZ2.26, CIZ1.2e4.2) in the total population.
CONCLUSIONS: Our data suggests that CHD is the major cardiovascular condition associated with asthma; a prospective study must be done to confirm a causal relationship.
Respir Med. 2012 Jul;106(7):948-53. doi: 10.1016/j.rmed.2012.02.017. Epub 2012 Mar 24.
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急性发作或自发性气胸的住院治疗对COPD或哮喘患者生命质量、心理功能、以及抑郁和焦虑症状的影响
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