哮喘联盟

   摘要
   背景：以往的研究显示皮肤点刺试验（SPT）阳性结果是小麦和黑麦粉相关职业性哮喘（OA）特异性激发试验(SIC)阳性的一个良好预测因子。非洲轻木引起OA的相似关联尚未被研究。研究旨在描述非洲轻木诱导的OA的临床表现，研究SPT结果是否可作为SIC试验结果的预测因子。
   方法：OA诊断取决于患者的病史，肺功能检测，SIC试验和非洲轻木SPT的测定。针对不同大小风团的SPT评估敏感性、阳性预测值（PPV）和阴性预测值（NPV），用SIC测试结果制作ROC特征曲线作为金标准。  
   结果：在34例有症状的工人中进行非洲轻木SIC试验，其中27例试验结果阳性的工人被诊断为OA。PPV 100%的最小cut-off值为SPT 风团3.5mm。这意味着所有非洲轻木SPT风团≥3.5mm的所有工人均为SIC阳性。  
   结论：有症状的工人SPT结果阳性是SIC阳性的良好预测因子。非洲轻木SIC试验高强敏感性的工人中可能是不必要的。
 

（苏楠 审校）
Occup Med (Lond). 2013 Sep;63(6):429-31. doi: 10.1093/occmed/kqt050. Epub 2013 Jun 15.


 

Prediction of obeche wood-induced asthma by specific skin prick testing.
 

Hannu T, Lindström I, Palmroos P, Kuuliala O, Sauni R.
 

ABSTRACT
BACKGROUND：It has previously been shown that a positive skin prick test (SPT) result is a good predictor of a positive specific inhalation challenge (SIC) in patients with occupational asthma (OA) related to wheat or rye flours. This association has not been previously studied in OA attributable to obeche wood. Aims To describe a clinical series of patients with OA induced by obeche wood. To investigate if the SPT result can be used as a predictor for the outcome of SIC tests.
METHODS：OA was diagnosed according to patient history, lung function examinations and SIC tests, as well as the determination of obeche SPTs. We analysed sensitivity, specificity and positive (PPV) and negative predictive values (NPV) at different wheal sizes of the SPTs and drew receiver-operating characteristic plots using the SIC test result as the gold standard.
RESULTS：Obeche wood SIC tests were performed on 34 symptomatic workers. Of these, 27 workers had a positive test result and were diagnosed as having OA. The minimal cut-off value with a PPV of 100% was an SPT wheal of 3.5 mm from obeche wood. This means that all workers with a wheal size of ≥3.5 mm from obeche wood had a positive SIC.
CONCLUSIONS：Positive SPT results in symptomatic workers were good predictors of a positive SIC. SIC with obeche wood may be unnecessary in strongly sensitized workers.
 

Occup Med (Lond). 2013 Sep;63(6):429-31. doi: 10.1093/occmed/kqt050. Epub 2013 Jun 15.