哮喘联盟

   摘要
   简介：实现和维持好的哮喘控制是哮喘管理中的一个主要目标。然而，因为哮喘药物的不适当使用和不依从，许多患者哮喘控制不佳。该研究的目的是为了评估药剂师的干预对成年哮喘患者的影响。
   方法：为期6个月的群组随机、对照试验随着社区药店的配置到干预或控制组而开展。干预组中的成年哮喘患者接受哮喘控制，吸入技术和服药依从性相关的个人需求为基础的干预措施。对照组中的患者接受常规治疗。在基线、3个月和6个月时评估主要变量。
   结果：336例患者完成了本研究，其中对照组150例，干预组186例。干预增强哮喘控制：接受干预的患者6个月后控制哮喘的优势比为3.06 (95% CI:1.63-5.73; p < 0.001)。干预组中平均ACQ评分显著增加[0.66分(SD: 0.78); p < 0.001]且6个月后哮喘控制的人数增加了30.1% (p < 0.001)。同时，干预亦改善服药依从性(增加了40.3%, p < 0.001)和吸入技术(增加了56.2%, p < 0.001)。然而，在对照组中，这些变量没有一个显著改善。
   结论：该项研究强调哮喘管理的重要结果。结果表明，与常规治疗相比，通过有计划的干预，社区药剂师能够提高哮喘控制的患者人数。
 

（苏楠 审校）
Respir Med. 2013 Sep;107(9):1346-55. doi: 10.1016/j.rmed.2013.05.014. Epub 2013 Jun 28.

 

Effect of a pharmacist intervention on asthma control. A cluster randomised trial.
 

García-Cárdenas V, Sabater-Hernández D, Kenny P, Martínez-Martínez F, Faus MJ, Benrimoj SI.
 

ABSTRACT
INTRODUCTION: Achievement and maintenance of good asthma control is a major objective in asthma management. However, asthma control in many patients is suboptimal, due to improper use of asthma medications and non-adherence. The aim of this study was to evaluate the effect of a pharmacist intervention on asthma control in adult patients.
METHODS: A 6-month cluster randomized controlled trial was undertaken with allocation of community pharmacies to intervention or control group. Adult asthma patients in the intervention group received a protocol-based intervention addressing individual needs related to asthma control, inhaler technique and medication adherence. Patients in the control group received usual care. Main variables were measured at baseline, 3 and 6 months.
RESULTS: 336 patients completed the study, 150 in the control group and 186 in the intervention group. The intervention resulted in enhanced asthma control: Patients receiving the intervention had an Odds ratio of 3.06 (95% CI:1.63-5.73; p < 0.001) of having controlled asthma six months later. In the intervention group mean ACQ scores significantly improved [0.66 points (SD: 0.78); p < 0.001] and the number of controlled asthma patients increased by 30.1% (p < 0.001) after 6 months. The intervention also resulted in improved medication adherence (by 40.3%, p < 0.001) and inhaler technique (by 56.2%, p < 0.001). No significant changes for any of these variables were observed in the control group.
CONCLUSION: The AFasma study focused on the important outcomes of asthma management, and showed that through the designed intervention, community pharmacists can increase controlled asthma patients compared to usual care.
 

Respir Med. 2013 Sep;107(9):1346-55. doi: 10.1016/j.rmed.2013.05.014. Epub 2013 Jun 28.