哮喘联盟

   摘要
   目的： 这项随机交叉试验的目的是为了比较新单剂量干粉吸入器(EH)和使用广泛的多剂量干粉吸入器(Diskus (DK)的临界误差、患者偏好和对吸入器的满意度。
   方法：首先，患者阅读一种吸入器的说明书，然后尝试使用第一种吸入器。评估吸入误差，若出现误差，当场演示纠正吸入器。然后由患者再次演示一次并记录误差，这样一直重复到第四次。待完成第一种吸入器评估后，以同样的步骤开始第二种吸入器的使用。主要终点是患者阅读说明书后，至少出现一次临界误差的比率。次要终点是对吸入器的偏好和满意度。
   结果：阅读说明书后，113例患者中有19例(17%)使用DK至少出现一次临界误差，使用EH有40例（35%） (p = 0.001)。73%的受试者偏爱DK，27%的偏爱EH (p < 0.001)。DK的平均总体满意度分值为1.59，EH为2.48 (p < 0.001)。
   结论：使用DK的受试者很少出现误差。更多的患者偏爱DK超过了EH，且患者对DK更满意。这可能与DK改善治疗结果高于EH有关。
 

（苏楠 审校）
Expert Opin Drug Deliv. 2013 Sep;10(9):1171-8. doi: 10.1517/17425247.2013.817387. Epub 2013 Jul 2.
 

A randomised cross-over trial investigating the ease of use and preference of two dry powder inhalers in patients with asthma or chronic obstructive pulmonary disease.
 

van der Palen J, van der Valk P, Goosens M, Groothuis-Oudshoorn K, Brusse-Keizer M.
 

Abstract
OBJECTIVES: The objective of this randomised, cross-over study was to compare a new single-dose dry powder inhaler (Elpenhaler (EH)), with a widely used, multi-dose dry powder inhaler (Diskus (DK)) on critical errors, patient preference, and satisfaction with the inhalers.
METHODS: First, patients read the instructions of one device, followed by a first inhalation attempt. Inhalation errors were assessed and if mistakes were made, correct inhaler use was demonstrated. Then patients had to demonstrate again and mistakes were registered. This was repeated up to four times. After completing the first device, the same procedure was started with the second inhaler. Primary outcome was the percentage of patients making at least one critical error after reading the insert. Secondary outcomes were inhaler preference and satisfaction with the inhalers.
RESULTS: After reading the insert, 19 of 113 patients (17%) made at least one critical error with DK and 40 (35%) with EH (p = 0.001); 73% preferred the DK and 27% the EH (p < 0.001). The mean overall satisfaction score (1 = very satisfied; 5 = very dissatisfied) for DK was 1.59 and for EH 2.48 (p < 0.001).
CONCLUSION: With DK fewer errors were made, more patients preferred DK over EH and patients were more satisfied with DK. This may enable DK to improve treatment outcomes more than EH.
 

Expert Opin Drug Deliv. 2013 Sep;10(9):1171-8. doi: 10.1517/17425247.2013.817387. Epub 2013 Jul 2.