哮喘联盟

   摘要
   结论：氟替卡松丙酸滴鼻剂(FPND)和功能性鼻内窥镜手术(FESS)的联合治疗可以改善生命质量(QoL)。与先前的数据相比，结果显示，为了获得患者对疾病和治疗的感知情况，QoL心理方面的常规评定要好于呼吸道症状和临床指标评定。
   目的:为更好了解FPND和FESS对一般生命质量评分的影响。
   方法:一项为期14周的随机、双盲、安慰剂对照研究，60例伴有哮喘的鼻息肉患者参与并完成总体幸福感量表(GWBS)
   结果:GWBS 评分：(i)在FPND治疗后显著增加，且不依赖于FESS治疗(从低于正常至正常)。(ii)在FESS治疗后增加，且不依赖于FPND治疗(从低于正常至正常)。(iii)在FPND和FESS联合治疗后累积增加。
 

（林江涛 审校）
Acta Otolaryngol. 2013 Sep;133(9):939-43. doi: 10.3109/00016489.2013.783715.
 

Effects of FESS and additional fluticasone propionate nasal drops on psychological well-being in nasal polyposis with asthma.
 

Nordin S, Olsson P, Hedén Blomqvist E, Stjärne P, Ehnhage A; NAF2S2 Study Group†.
 

Abstract
Abstract Conclusion: A combined therapy of fluticasone propionate nasal drops (FPND) and functional endoscopic sinus surgery (FESS) can improve quality of life (QoL). When compared with prior data, the results imply that a generic measure of psychological aspects of QoL may be better than measures of respiratory symptoms and clinical parameters to capture a patient's perception of the disease and its treatment.
Objective: To better understand effects of FPND and FESS on generic QoL.
Methods: Sixty nasal polyposis patients with concomitant asthma completed participation in a randomized, double-blind, placebo-controlled, 14-week study in which they responded to the General Well-Being Schedule (GWBS).
Results: GWBS scores (i) increased significantly after administration of FPND, independent of FESS (from lower than normal to normal), (ii) increased after FESS independent of FPND (from lower than normal to normal), and (iii) increased additively after FPND and FESS.
 

Acta Otolaryngol. 2013 Sep;133(9):939-43. doi: 10.3109/00016489.2013.783715.