哮喘联盟

   摘要
   背景：哮喘控制问卷（ACQ）是一个以患者为中心的哮喘控制评估工具。它在成人中已被验证，但在儿童中尚未得到很好验证。
   目标：我们评估了ACQ在评估6～17岁儿童哮喘控制时的可靠性、有效性和对变化的反应性，并确定了疾病控制不佳的阈值以及最小重要变化值。
   方法：本研究对来自一项临床研究的305例哮喘患儿的数据进行了检查。8次拜访均进行ACQ调查。我们分别分析了合并年龄组、6～11岁年龄组和12～17岁年龄组患儿的研究结果。
   结果：总体来说，ACQ问卷基线Cronbach α值（内部连贯性）为0.74，病情稳定患者的重复问卷的同类相关系数（再测可信度）为0.53。ACQ和其它哮喘问卷的相关系数（Pearson correlations）为中到重度（-0.64到 -0.73）。相比病情的稳定患者，最大呼气流量降低、更多使用急救药物或更多寻求哮喘治疗的患者平均ACQ得分更高（病情更严重）（所有情况均P<.0001）。处于病情恶化、改善或稳定患者的ACQ得分变化显著不同（P≤ .01）。提示哮喘控制不佳的最佳阈值为1.25或更大。最小重要变化值被定为0.40。不同年龄组结果相似。
   结论：ACQ是评估儿童近期哮喘控制的一种中等可靠、有效和敏感工具，并具有足够的心理测量学特征。

 

（苏楠 审校）
JAllergyClinImmunol.2013Aug6.pii:S0091-6749(13)00997-4.doi:10.1016/j.jaci.2013.06.029. [Epub ahead of print]

 

Validation and psychometric properties of the Asthma Control Questionnaire among children.
 

Nguyen JM, Holbrook JT, Wei CY, Gerald LB, Teague WG, Wise RA; on behalf of the American Lung Association Asthma Clinical Research Centers.
 

Abstract
BACKGROUND: The Asthma Control Questionnaire (ACQ) is a patient-centered tool for evaluating asthma control. It has been validated in adults, but not well-validated among children.
OBJECTIVE: We evaluated the reliability, validity, and responsiveness to change of the ACQ for assessing asthma control in children ages 6 to 17 years. A threshold value for poor disease control and a minimally important difference were also determined.
METHODS: Data from 305 asthmatic children enrolled in a clinical trial were examined. The ACQ was administered at 8 visits. We analyzed results for the combined age group and for the 6- to 11-year-old and 12- to 17-year-old age groups separately.
RESULTS: Overall, the Cronbach α value (internal consistency) for the ACQ was 0.74 at baseline, and the intraclass correlation coefficient (test-retest reliability) for repeated questionnaires among stable patients was 0.53. The Pearson correlations between the ACQ and other asthma questionnaires were moderate to strong (-0.64 to -0.73). Mean ACQ scores were higher (worse) in patients whose peak flow decreased, who used more rescue medications, or who sought medical care for asthma than in patients who were stable (P < .0001 for all measures). Changes in ACQ scores were significantly different among patients with deteriorating, improving, or stable asthma symptoms (P ≤ .01). The optimal threshold indicating poor asthma control was 1.25 or greater. The minimally important difference was established to be 0.40. Results for the separate age groups were similar.
CONCLUSION: The ACQ is a moderately reliable, valid, and responsive tool with adequate psychometric properties for assessing recent asthma control among children.
 

JAllergyClinImmunol.2013Aug6.pii:S0091-6749(13)00997-4.doi:10.1016/j.jaci.2013.06.029. [Epub ahead of print]