哮喘联盟

   摘要
   简介：虽然流行病学研究已经表明，室外低温与住院率和死亡率增加有关(尤其呼吸道和心血管疾病)，但很少有研究关注室内温度和健康的关系。这样的研究显然是合理的，因为人们更多的时间是暴露在室内环境而不是室外环境。
   目的：旨在评估各种不同室内温度的指标与哮喘患儿肺功能之间的关系。具体的研究问题包括：（1）哪个房间的温度与肺功能最相关？(2)哪种暴露指标最能描述室内温度与肺功能的关系？(3)哪个时间段的室内温度对肺功能影响最明显？
   方法：住房加热和健康研究是一个随机对照研究，该研究调查了室内安装加热器对儿童哮喘的影响。研究收集了肺功能（每日）和室内温度（每小时）的测量值。对超过12049天的309例儿童进行了肺功能和室内温度的测量。使用统计模型来确认最佳的措施和指标。
   结果：与肺功能关联性最强的是卧室低温的暴露程度，平均预测范围为0-7到0-12天。温度每增加11°C，四个肺功能测量指标早晨最大呼气流速 (PEFR) ，晚间PEFR， 早晨第一秒用力呼气容积(FEV1) 和晚间FEV1，分别增加0.010, 0.008, 10.06, 12.06 。
   结论：室内温度意义重大，与哮喘患儿肺功能短期变化有关。
 

（林江涛 审校）
J Epidemiol Community Health. 2013 Aug 12. doi: 10.1136/jech-2013-202632. [Epub ahead of print]

 

Modelling the effects of low indoor temperatures on the lung function of children with asthma.
 

Pierse N, Arnold R, Keall M, Howden-Chapman P, Crane J, Cunningham M; the Heating Housing and Health Study Group.
 

Abstract

INTRODUCTION: While many epidemiological studies have shown that low outdoor temperatures are associated with increased rates of hospitalisation and mortality (especially for respiratory or cardiovascular disease), very few studies have looked at the association between indoor temperatures and health. Such studies are clearly warranted, as people have greater exposure to the indoor environment than the outdoor environment.
OBJECTIVES: To examine the relationship between various metrics of indoor temperature and lung function in children with asthma. Our specific research questions were: (1) In which room of the home is temperature most strongly associated with lung function? (2) Which exposure metric best describes the relationship between indoor temperature and lung function? (3) Over what lag/time period does indoor air temperature affect lung function most strongly?
METHODS: The Heating Housing and Health Study was a randomised controlled trial that investigated the effect of installing heaters in the homes of children with asthma. This study collected measurements of lung function (daily) and indoor temperature (hourly). Lung function and indoor temperature were measured for 309 children over 12 049 child-days. Statistical models were fitted to identify the best measures and metrics.
RESULTS: The strongest association with lung function was found for the severity of exposure to low bedroom temperatures averaged over the preceding periods of 0-7 to 0-12 days. A 1°C increase in temperature was associated with an average increase of 0.010, 0.008, 10.06, 12.06, in our four measures of lung function (peak expiratory flow rate (PEFR) morning, PEFR evening, forced expiratory volume in 1 s (FEV1) morning and FEV1 evening).
CONCLUSIONS: Indoor temperatures have a small, but significant, association with short-term variations in the lung function of children with asthma.
 

J Epidemiol Community Health. 2013 Aug 12. doi: 10.1136/jech-2013-202632. [Epub ahead of print]