哮喘联盟

   摘要
   研究背景：哮喘患者气道粘膜血管增加可能增加气道热量流失
   研究目的：本研究旨在确定哮喘未控制患者气道炎症是否增加呼出气息的温度（EBT）
   患者和方法：研究纳入100例持续性哮喘患者和50例健康志愿者，采用支气管扩张剂后用力呼吸量测量法测定肺功能，并进行哮喘控制测试(ACT)和EBT测试
   结果：哮喘患者中49%为女性，平均（±平均标准误差）年龄44岁(±17)，预测的1秒用力呼气量为71%(±16)，EBT显著增加，特别是哮喘未控制的患者中(n = 50, ACT ≥ 20, EBT 33.7 ± 0.8°C)，相比哮喘控制患者(n = 50, ACT ≥ 20, EBT 33.7 ± 0.8°C)和健康志愿者(n = 50, EBT 33.2 ± 0.2°C, P < 0.001)ETB增加明显
   结论：与哮喘控制患者和健康受试者相比，哮喘未控制者呼出气息的温度更高。呼出气息温度的增加可能是哮喘患者气道炎症加重的反映。 
 

                (林江涛 审校)
Int J Tuberc Lung Dis. 2013 Jul;17(7):969-72. doi: 10.5588/ijtld.12.0657.

 

Increased exhaled breath temperature in subjects with uncontrolled asthma.

García G, Bergna M, Uribe E, Yañez A, Soriano JB.
 

Abstract
BACKGROUND: Increased vascularity of the airway mucosa in asthma potentially increases heat loss in the airways.
OBJECTIVE: To determine if the inflamed airways of subjects with uncontrolled asthma show increased exhaled breath temperature (EBT).
PATIENTS AND METHODS: In 100 patients with persistent asthma and 50 healthy volunteers, we measured lung function by post-bronchodilator forced spirometry, the asthma control test (ACT) and EBT.
RESULTS: Patients with asthma, of whom 49 (49%) were female, with a mean (± standard error of the mean) age of 44 (±17) years and a predicted forced expiratory volume in one second of 71% (±16), had a significantly increased EBT, particularly those with uncontrolled asthma (n = 50, ACT ≤ 19, EBT 34.9 ± 0.8°C), compared to patients with controlled asthma (n = 50, ACT ≥ 20, EBT 33.7 ± 0.8°C) and healthy volunteers (n = 50, EBT 33.2 ± 0.2°C, P < 0.001).
CONCLUSION: We observed a higher temperature on exhaled breath in subjects with uncontrolled asthma than in subjects with controlled asthma and healthy controls. The increase in exhaled breath temperature may be a proxy for a raised airway inflammatory state in asthma patients.
 

Int J Tuberc Lung Dis. 2013 Jul;17(7):969-72. doi: 10.5588/ijtld.12.0657.