哮喘联盟

   摘要
   浆细胞样树突状细胞（pDCs）主要是由1型干扰素产生的细胞，在抗病毒免疫和耐受中起重要作用的。这些细胞与传统树突状细胞（DCs）有共同起源，Fms样酪氨酸激酶-3配体与它们的发生密切相关。pDCs的几个亚群已经明确，包括CCR9+ , CD9+ , 和 CD2+。近来，学者们描述了三个名为CD8α- β- , CD8α+ β- , 和CD8α+ β+的亚群。有趣的是，实验诱导过敏性哮喘中发现CD8α+ β-和 CD8α+ β+有致耐受作用，而CD8α- β-没有。这种致耐受作用看来是由经视黄酸的FOXP3+ 调节性T细胞的生成所介导，由视黄醛脱氢酶所诱导。这些新的pDCs亚群展示了过敏性疾病的新的治疗方式的较高的可能性。本综述将阐述我们对过敏性疾病，特别是过敏性哮喘研究中pDC生物学的了解。

 

（刘国梁 审校）
Allergy. 2013 May 11. doi: 10.1111/all.12166. [Epub ahead of print]

 

Role of plasmacytoid dendritic cell subsets in allergic asthma.

Maazi H, Lam J, Lombardi V, Akbari O.

Abstract
Plasmacytoid dendritic cells (pDCs) are major type-I interferon-producing cells that play important roles in antiviral immunity and tolerance induction. These cells share a common DC progenitor with conventional DCs, and Fms-like tyrosine kinase-3 ligand is essential for their development. Several subsets of pDCs have been identified to date including CCR9+ , CD9+ , and CD2+ pDCs. Recently, three subsets of pDCs were described, namely CD8α- β- , CD8α+ β- , and CD8α+ β+ subsets.Interestingly, CD8α+ β- and CD8α+ β+ but not CD8α- β- pDCs were shown to have tolerogenic effects in experimentally induced allergic asthma. These tolerogenic effects were shown to be mediated by the generation of FOXP3+ regulatory T cells through retinoic acid and the induction of retinaldehyde dehydrogenase enzymes. These newly described subsets of pDCs show high potentials for novel therapeutic approaches for the treatment of allergic diseases. In this review, we will address the new progress in our understanding of pDC biology with respect to allergic disease, in particular allergic asthma.

Allergy. 2013 May 11. doi: 10.1111/all.12166. [Epub ahead of print]