哮喘联盟

   摘要
   综述目的：哮喘是与肺功能减退、多发症状、控制程度多变、急性发作风险相关联的复杂的疾病。预测急性发作风险将改善哮喘管理，在干预研究中帮助识别这些患者。
   研究进展：不同临床表现的哮喘伴随因素存在差异。提示气道高反应性的生物标记并不与未来发作风险直接相关。与发作风险相关的基因因子开始显现。能够预测结局的方法已经出现，将有助于患者管理，为临床试验提供新的有意义的研究终点。
   小结：本综述将强化对哮喘加重有关的潜在因素和与严重发作风险相关的临床预测规则的理解。

 

（林江涛 审校）
Curr Opin Allergy Clin Immunol. 2013 Apr 30. [Epub ahead of print]


 

Asthma exacerbations: predisposing factors and prediction rules.

Greenberg S.

Abstract
PURPOSE OF REVIEW:Asthma is a multifaceted disease that is associated with decreased lung function, multiple symptoms, varying levels of asthma control, and risk of acute exacerbations. The ability to predict the risk of developing acute exacerbations may improve the management of asthmatics and facilitate identification of these patients for interventional studies.
RECENT FINDINGS: Factors that are associated with different manifestations of asthma differ.Biomarkers that are correlated with airways hyper-responsiveness do not necessarily correlate with risk of future exacerbations. Genetic factors that segregate with exacerbation risk are beginning to emerge. Outcome measures that demonstrate predictive validity have been developed and may facilitate patient management and provide novel clinically meaningful endpoints in clinical trials.
SUMMARY: This review will emphasize underlying factors associated with asthma exacerbations and clinical prediction rules that correlate with the risk of developing severe exacerbations.

Curr Opin Allergy Clin Immunol. 2013 Apr 30. [Epub ahead of print]