哮喘联盟

   摘要
   过去，人类呼吸道模型的发展基于对健康人群的气管和支气管的测量。除少数形态学的特征例如支气管壁厚度(ST)外，支气管树状结构和几何学特征对疾病的影响很少被报道。本研究对7例健康患者和6例中度持续性哮喘患者进行高分辨率CT扫描，使用商业软件程序对气道树状结构进行分析，同时也对哮喘的治疗进行评估。体外研究结果如支气管长度、直径、WT、分支和转角度均被记录，并比较每一代不同的肺叶情况。另外，为了证实两组的正确性，这些形态特征中的一些受关注的数学关系也被检测。研究结果提示，尽管一些关联完全与以前发布的数据一致，但支气管在肺叶中的划分和疾病的发生可能显著影响支气管树状结构，而疾病只是轻微影响树状结构和气道的连贯性。

 

(刘国梁 审校)
Anat Rec (Hoboken). 2013 Apr 8. doi: 10.1002/ar.22695. [Epub ahead of print]

Airway Morphology From High Resolution Computed Tomography in Healthy Subjects and Patients With Moderate Persistent Asthma.
 

Montesantos S, Katz I, Fleming J, Majoral C, Pichelin M, Dubau C, Piednoir B, Conway J, Texereau J, Caillibotte G.

Abstract
Models of the human respiratory tract developed in the past were based on measurements made on human trachea bronchial airways of healthy subjects. With the exception of a few morphometric characteristics such as the bronchial wall thickness (WT), very little has been published concerning the effects of disease on the tree structure and geometrical features.
 In this study, a commercial software package was used to segment the airway tree of seven healthy and six moderately persistent asthmatic patients from high resolution computed tomography images. The process was assessed with regards to the treatment of the images of the asthmatic group. The in vivo results for the bronchial length, diameter, WT, branching, and rotation angles are reported and compared per generation for different lobes. Furthermore, some popular mathematical relationships between these morphometric characteristics were examined in order to verify their validity for both groups. Our results suggest that, even though some relationships agree very well with previously published data, the compartmentalization of airways into lobes and the presence of disease may significantly affect the tree geometry, while the tree structure and airway connectivity is only slightly affected by the disease.

Anat Rec (Hoboken). 2013 Apr 8. doi: 10.1002/ar.22695. [Epub ahead of print]