对乙酰氨基酚与哮喘的关系：应该被禁止用于儿科吗？
2013/06/25
摘要
在过去的几十年中，全球开展了一项大规模流行病学研究以确定哮喘（俗称“喘息障碍”）发生发展的重要因素。对基因的研究未发现任何值得注意的有较强作用的基因信号，一些微小的基因信号还没有被适当的复制。对环境的研究发现一些诸如感染、过敏原和细菌物质之类的多种因素，研究兴趣方向涉及哮喘保护和诱导的多个领域。几乎每项流行病学研究均发现一个长期的、持续性的环境因素，即既往对乙酰氨基酚的暴露史，可持续增加喘息性疾病的发生率和加重临床表现。对乙酰氨基酚到底是哮喘的促发者还是无辜旁观者？
The association between acetaminophen and asthma: should its pediatric use be banned?
Martinez-Gimeno A, García-Marcos L.
Abstract
During the last few decades, a huge epidemiological effort has been made all over the world in order to cast some light on the origin of asthma (or 'wheezing disorders' as a general term) and its recent increase in prevalence. The focus on genetic factors has failed to show any genetic signal strong enough to be seriously considered, and the tiny genetic signals found have never been appropriately replicated. The focus on environmental factors has provided some variable signals on the role of infections, allergens and bacterial substances, the direction of which have curiously varied from protecting to inducing asthma. The only environmental factor that has launched a large and consistent epidemiological signal, found in almost every epidemiological study addressing the issue, is previous acetaminophen exposure, which consistently increases the prevalence and clinical manifestations of every wheezing disorder under study. Is acetaminophen a real asthma promoter or an innocent bystander?
Expert Rev Respir Med. 2013 Apr; 7(2):113-22. doi: 10.1586/ers.13.8.
在过去的几十年中，全球开展了一项大规模流行病学研究以确定哮喘（俗称“喘息障碍”）发生发展的重要因素。对基因的研究未发现任何值得注意的有较强作用的基因信号，一些微小的基因信号还没有被适当的复制。对环境的研究发现一些诸如感染、过敏原和细菌物质之类的多种因素，研究兴趣方向涉及哮喘保护和诱导的多个领域。几乎每项流行病学研究均发现一个长期的、持续性的环境因素，即既往对乙酰氨基酚的暴露史，可持续增加喘息性疾病的发生率和加重临床表现。对乙酰氨基酚到底是哮喘的促发者还是无辜旁观者？
（苏楠 审校）
Expert Rev Respir Med. 2013 Apr; 7(2):113-22. doi: 10.1586/ers.13.8.
Expert Rev Respir Med. 2013 Apr; 7(2):113-22. doi: 10.1586/ers.13.8.
The association between acetaminophen and asthma: should its pediatric use be banned?
Martinez-Gimeno A, García-Marcos L.
Abstract
During the last few decades, a huge epidemiological effort has been made all over the world in order to cast some light on the origin of asthma (or 'wheezing disorders' as a general term) and its recent increase in prevalence. The focus on genetic factors has failed to show any genetic signal strong enough to be seriously considered, and the tiny genetic signals found have never been appropriately replicated. The focus on environmental factors has provided some variable signals on the role of infections, allergens and bacterial substances, the direction of which have curiously varied from protecting to inducing asthma. The only environmental factor that has launched a large and consistent epidemiological signal, found in almost every epidemiological study addressing the issue, is previous acetaminophen exposure, which consistently increases the prevalence and clinical manifestations of every wheezing disorder under study. Is acetaminophen a real asthma promoter or an innocent bystander?
Expert Rev Respir Med. 2013 Apr; 7(2):113-22. doi: 10.1586/ers.13.8.
(未知)
上一篇：
哮喘的物理治疗——寻求共识
下一篇：
雾化利多卡因应用于顽固性咳嗽和哮喘的证据
