哮喘联盟

   摘要
   目的：有关肥胖和哮喘对高脂血症的联合作用未曾被探讨。本研究旨在评价：(1)血脂异常和哮喘的关系；(2)肥胖和哮喘对高脂血症的相互作用；(3) 上述相关性是否存在性别差异。
   方法：本研究入选了2009～2010年间台湾北部2家医院和7所学校中10～15岁的哮喘(n=237)和非哮喘对照儿童(n=225)，再进一步分为四组：非肥胖对照组、肥胖对照组、非肥胖哮喘组和肥胖哮喘组。检测方法包括人体检测和用血液样本分析代谢因素。库克指标用于界定儿童代谢综合征。采用普通线性模型分析血脂与肥胖和哮喘之间的相关性。
   结果：四组受试者的总胆固醇和低密度脂蛋白胆固醇水平按照下列顺序依次递增：肥胖哮喘组>非肥胖哮喘组>肥胖对照组>非肥胖对照组。男孩中，肥胖哮喘组的低密度脂蛋白胆固醇水平要明显高于肥胖对照组，普通线性模型显示其平均差异为6.2 mmol/L。同时还发现，男孩中肥胖和哮喘与高脂血症间有着明显的相互影响（p =0.03）。
   结论：哮喘与更高的低密度脂蛋白胆固醇水平相关，且该相关性在超重和肥胖受试者中更为明显。经观察发现，肥胖和哮喘与高脂血症之间的相互关系存在性别差异。

（苏楠 审校）
Diabetes Metab Syndr. 2013 Jan-Mar;7(1):20-5. doi: 10.1016/j.dsx.2013.02.026. Epub 2013 Mar 9.


 

Lipid profiles in children with and without asthma: Interaction of asthma and obesity on hyperlipidemia.

Chen YC, Tung KY, Tsai CH, Su MW, Wang PC, Chen CH, Lee YL.

Source
Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Family Medicine, Taipei City Hospital, ZhongXing Branch, Taipei, Taiwan.

Abstract
AIMS:The joint effect of obesity and asthma on hyperlipidemia has never been explored. We aim to examine (1) the association of dyslipidemia and asthma, (2) the interaction effect of asthma and obesity on hyperlipidemia, and (3) whether a gender difference existed in the above relationships.
METHODS:Between 2009 and 2010, 10- to 15-year-old children were recruited from 7 schools and 2 hospitals in Northern Taiwan. The population consisted of 237 asthmatic children and 225 non-asthmatic controls, and was further divided into four groups: non-obese controls, obese controls, non-obese asthmatics, and obese asthmatics. Measurements included anthropometric measures and blood samples for analysis of metabolic factors. The Cook's criteria were used to define childhood metabolic syndrome. General linear models were used to analyze how lipid profiles were associated with obesity and asthma.
RESULTS:Total cholesterol and low density lipoprotein cholesterol levels increased progressively in the group order obese asthmatics>non-obese asthmatics>obese controls>non-obese controls. In boys, low density lipoprotein cholesterol levels were significantly higher in obese asthmatics compared to obese non-asthmatics, with a mean difference of 6.2mmol/L in the general linear model. We also discovered a significant interactive effect of obesity and asthma on hyperlipidemia in boys (p for interaction=0.03).
CONCLUSIONS:Asthma was associated with higher low density lipoprotein cholesterol levels and this association was amplified in overweight and obese subjects. A gender difference was observed in the joint effect of obesity and asthma on hyperlipidemia.
 

Diabetes Metab Syndr. 2013 Jan-Mar;7(1):20-5. doi: 10.1016/j.dsx.2013.02.026. Epub 2013 Mar 9.