哮喘联盟

   摘要
   一项前瞻性、多中心临床研究，初步评价了非侵袭性迷走神经刺激（nVNS）治疗哮喘支气管收缩急性加重的安全性和潜在临床获益。由于入组缓慢和装置设计的改变，导致该研究在入组了4例合格患者后被过早终止。其中3例患者得到了成功治疗，表现为FEV1和VAS呼吸困难评分改善，且并未出现装置相关性不良事件。ClinicalTrials.gov Identifier NCT01385306.
 

（刘国梁 审校）
Int J Emerg Med. 2013 Mar 19;6(1):7. [Epub ahead of print]


 

Non-invasive vagus nerve stimulation for the treatment of acute asthmaexacerbations--results from an initial case series.

Steyn E, Mohamed Z, Husselman C.

Abstract
A prospective multicentre clinical study was initiated to evaluate the safety and potential clinical benefit of non-invasive vagus nerve stimulation (nVNS) for the treatment of bronchoconstriction exacerbations in asthmatics. Due to slow enrolment and design changes of the device, the study was prematurely terminated after enrolment of four eligible patients. Three of the four patients were considered treatment successes based on improvement in FEV1, improvement in VAS dyspnoea scoring, and the absence of device-related adverse events. ClinicalTrials.gov Identifier NCT01385306.

Int J Emerg Med. 2013 Mar 19;6(1):7. [Epub ahead of print]