哮喘联盟

   摘要
   目的：本试验旨在儿童中研究诱导痰液嗜酸性粒细胞性炎症与肺功能和持续气流受限的关系。
   方法：92名哮喘患儿和72名对照入选本研究。检测诱导痰液中嗜酸性粒细胞数（%）和嗜酸性粒细胞阳离子蛋白（ECP）。此外，对所有受试者进行肺活量检测、乙酰甲胆碱激发试验及检测总嗜酸性粒细胞、总血清IgE和血清ECP。
   结果：与对照者相比，哮喘患儿痰液嗜酸性粒细胞水平较高（9% vs 0%; P < 0.001），痰液ECP含量也较高（2.3 ± 0.7 vs. 1.6 ± 0.6 log μg/L, P < 0.001）。痰液ECP水平与支气管扩张剂使用后（postBD）的FEV1（r = -0.307; P = 0.001）和postBD FEV1/FVC（r = -0.286; P = 0.002）呈显著负相关，而痰液嗜酸性粒细胞与postBD FEV1和postBD FEV1/FVC无显著相关性。此外，有和无持续气流受限的哮喘患儿，痰液ECP和痰液嗜酸性粒细胞计数无显著差异。
   结论：本研究结果显示，痰液嗜酸性粒细胞性炎症，特别是ECP，与肺功能和持续气流受限相关，表现为使用支气管扩张剂后FEV1/FVC下降。
 

（苏楠 审校 ）
J Asthma. 2013 Feb 18. [Epub ahead of print]

 

Association between Eosinophilic Airway Inflammation and Persistent Airflow Limitation.
 
Lee YJ, Lee HH, Choi BS, Jee HM, Kim KW, Sohn MH, Kim KE.

Source
Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital , Seoul.

Abstract 
OBJECTIVE: We aimed to evaluate the association between eosinophilic inflammation in induced sputum and pulmonary function and persistent airflow limitation in children.
METHODS: A total of 92 asthmatic children and 72 controls were enrolled in this study. Eosinophil count (%) and eosinophil cationic protein (ECP) levels were measured in induced sputum. We performed spirometry and a methacholine challenge test and measured total eosinophil count, total serum IgE, and serum ECP in all subjects.
RESULTS: Asthmatic children had significantly higher levels of sputum eosinophils (9% vs. 0%; P < 0.001) and sputum ECP (2.3 ± 0.7 vs. 1.6 ± 0.6 log μg/L, P < 0.001) than controls. Sputum ECP levels showed a significant negative correlation with postbronchodilator (postBD) FEV(1) (r = -0.307; P = 0.001) and postBD FEV1/FVC (r = -0.286; P = 0.002), whereas sputum eosinophils showed no correlation with postBD FEV(1) and postBD FEV(1)/FVC. However, no significant differences in sputum ECP and sputum eosinophil counts were observed in asthmatic children with and without persistent airflow limitation.
CONCLUSIONS: Our findings suggest that sputum eosinophilic inflammation, especially ECP, is associated with pulmonary function and persistent airflow limitation, which is manifested by low postBD FEV(1)/FVC.

J Asthma. 2013 Feb 18. [Epub ahead of print]