哮喘联盟

   摘要
   前言：高频胸壁振荡（HFCWO）已经用于某些呼吸系统疾病（如：囊性纤维化[CF]和支气管扩张）下气道分泌物的清除。但鲜有研究报道其在难治性哮喘中的应用。
   病例报道：一名36岁的男性非吸烟者，主诉长期哮喘控制较差。尽管使用多种哮喘控制治疗药物，仍主诉每日胸闷、痰多和哮喘频繁恶化。影像学检查、血液学检查和支气管镜检查排除非典型感染、免疫缺陷、CF和其他慢性疾病。肺功能检测支持哮喘诊断。
   结果：我们对该名患者进行HFCWO治疗，每日两次，同时采用药物吸入治疗。2个月后，患者主诉呼吸道症状缓解，检查显示肺功能改善。在2年的随访中未出现症状。
   结论：高频胸壁震荡可用于治疗粘液分泌较多的哮喘患者。
 

（苏楠 审校）
J Asthma. 2013 Mar;50(2):219-21. doi: 10.3109/02770903.2012.757773.

 

High-frequency chest wall oscillation successful in controlling refractory asthma.
 
Bose S, Jun J, Diette GB.

Source
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University , Baltimore, MD , USA.

Abstract 
INTRODUCTION：High-frequency chest wall oscillation (HFCWO) has been traditionally implemented for airway secretion clearance in conditions such as cystic fibrosis (CF) and bronchiectasis. There have been few reports of its use in refractory asthma.
CASE REPORT：A 36-year-old, non-smoker male presented with a lifelong history of poorly controlled asthma. Despite multiple controller medications, he reported daily chest congestion, copious phlegm, and frequent exacerbations. Imaging, blood work, and bronchoscopy ruled out atypical infections, immunodeficiency, CF, and other chronic conditions. Pulmonary function tests supported a diagnosis of asthma.
RESULTS：We initiated HFCWO therapy twice daily in addition to standard inhaled pharmacological therapy. After 2 months, the patient noted resolution of respiratory symptoms as well as improvement in lung function. He remained symptom-free at his 2-year follow-up.
CONCLUSION：High-frequency chest oscillation may be useful in phenotypes of asthma characterized by prominent mucus hypersecretion.
J Asthma. 2013 Mar;50(2):219-21. doi: 10.3109/02770903.2012.757773.