哮喘联盟

  摘要
  背景：职业性哮喘（OA）是指由于工作暴露导致哮喘新发作或前期静息期哮喘重新发作。
  目的：本试验基于人群，研究新发性OA和工作相关性哮喘的发病率。
  方法：收集美国38个州和哥伦比亚特区2006-2009年内，年龄≥18岁的受试者的行为危险因子调查系统和哮喘回顾调查数据，并进行分析。新近发作的确诊OA指过去12个月内首次诊断有哮喘，而且专业人士认为该哮喘与其工作相关。潜在的、新近发作的OA患者指过去12个月内诊断有哮喘，但专业人士并未诊断为工作相关的哮喘，而是描述其哮喘与工作环境暴露相关。基于2006～2008年成人哮喘发病率（百万分之3800）计算工作相关的哮喘发病率。
  结果：专家诊断的新发性OA，其发生率估计为百万分之179（95% CI: 113-245）。专家诊断的以及潜在的新发性OA，其发生率估计为百万分之692（95% CI: 532-853）。在成人，专家诊断的新发性哮喘发生率为4.7%，所有新发性哮喘发生率为18.2%。
  结论：1/6的哮喘成人患者中，新发性哮喘可能与工作相关。临床医生在诊断哮喘时应该考虑到职业暴露，这有助于早期干预，逆转其向慢性哮喘发展。
 

（苏楠 审校）
J Asthma. 2013 Feb 22. [Epub ahead of print]

 

Occupational Asthma Incidence: Findings from the Behavioral Risk Factor Surveillance System Asthma Call-Back Survey-United States, 2006-2009.
 
Mazurek JM, Knoeller GE, Moorman JE, Storey E.

Source
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention , Morgantown, WV , USA.

Abstract 
BACKGROUND： Occupational asthma (OA) is new-onset asthma or the recurrence of previously quiescent asthma caused by workplace exposures.
OBJECTIVE：To estimate the incidence of population-based new-onset OA and the proportion of incident asthma that is work-related.
METHODS：Behavioral Risk Factor Surveillance System and Asthma Call-back Survey data collected from persons aged ≥18 years during 2006-2009 in 38 states and the District of Columbia were analyzed. Incident health professional-diagnosed new-onset OA cases were persons whose asthma was diagnosed for the first time within the past 12 months whose health professional indicated their asthma was related to their work. Incident potential new-onset OA cases were persons with asthma diagnosed within the past 12 months who did not have health professional-diagnosed work-related asthma but described their asthma as caused by workplace exposures. The proportion of incident asthma that is work-related was calculated using the 2006-2008 estimate of adult asthma incidence (3800 per million).
RESULTS：The estimated annual incidence of health professional-diagnosed new-onset OA was 179 (95% CI: 113-245) per million population. For combined health professional-diagnosed and potential new-onset OA the incidence was 692 (95% CI: 532-853) per million population. The proportion of incident asthma among adults that is work-related was 4.7% for health professional-diagnosed new-onset OA and 18.2% for combined health professional-diagnosed and potential new-onset OA.
CONCLUSIONS：New-onset asthma in as many as one of six adult patients might be associated with work. Clinicians should consider the role of occupational exposures when evaluating adults with incident asthma which may uncover opportunities for early intervention and reversal of an otherwise chronic disease.

J Asthma. 2013 Feb 22. [Epub ahead of print]