哮喘联盟

摘要
   目的：幽门螺杆菌感染已经成为全球范围内的一大公共卫生威胁。一些研究显示，哮喘患者的幽门螺杆菌感染率较低。但两者的关系尚存在争议。此项荟萃分析旨在评价幽门螺杆菌感染与哮喘之间的关系。
   方法：收集有关哮喘患者幽门螺杆菌患病的相关信息，评价幽门螺杆菌与哮喘风险之间的关系。14项研究满足入选标准。收集研究人群的数据、幽门螺杆菌检测方法和出版年相关信息。荟萃回归模型和亚组分析筛查导致异质性的因素。
   结果：共获取106篇文献，14篇文献满足入选标准。14项研究共涉及28283名患者，幽门螺杆菌感染率为40.53%。荟萃分析显示，哮喘患者的幽门螺杆菌感染率显著低于对照者（优势比：0.84, 95%CI：0.73-0.96, P=0.013）亚组分析显示，哮喘患者与对照者的Cag A阳性率无显著差异（优势比：0.73，95%CI：0.41-1.28, P=0.03).
   结论：汇总数据显示，哮喘患者有较低的幽门螺杆菌感染率。有必要进行大规模的多中心研究，进一步确定幽门螺杆菌感染与过敏性疾病的关系。

（刘国梁 审校）
 Eur J Gastroenterol Hepatol. 2012 Dec 13. [Epub ahead of print]

 

Association between Helicobacter pylori and asthma: a meta-analysis.

Zhou X, Wu J, Zhang G.

Source
aDepartment of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University bDepartment of Gastroenterology, First Clinical Medical College of Nanjing Medical University, Nanjing, China.

Abstract
OBJECTIVE: Helicobacter pylori infection is recognized as a worldwide public health threat. Some studies have suggested that individuals with asthma have a lower rate of H. pylori infection, but the relation remains controversial. This meta-analysis was carried out to quantify the association between H. pylori infection and asthma.
METHODS: Published information on the prevalence of H. pylori in individuals with asthma was collected to assess the potential associations between H. pylori infection and the risk of asthma. Fourteen eligible studies were selected for analysis. Data on the study populations, detection method of H. pylori, and publication year were summarized. Meta-regression models and subgroup analyses were established to screen the factors resulting in heterogeneity.
RESULTS: Of the 106 articles retrieved, 14 fulfilled the inclusion criteria. The 14 studies involved 28 283 patients, with a total H. pylori infection rate of 40.53%. This meta-analysis found a significantly lower rate of H. pylori infection in the asthmatics than in the controls (odds ratio=0.84, 95% confidence interval: 0.73-0.96, P=0.013). Subgroup analysis indicated a similar infection rate of CagA-positive H. pylori infection in the asthmatic group and the control group (odds ratio=0.73, 95% confidence interval: 0.41-1.28, P=0.03).
CONCLUSION: The pooled data suggest that asthmatics have a significantly lower rate of H. pylori infection. Large-scale and multicenter studies should be carried out to further determine the relation between this bacterium and allergic disorders.

Eur J Gastroenterol Hepatol. 2012 Dec 13. [Epub ahead of print]