哮喘联盟

摘要
   前言：越来越多的证据表明抑郁症状和性激素与复吸风险有关，然而两者相关性的具体机制尚不清楚。本试验为随机交叉研究，在有和无抑郁症状的女性吸烟者中，评价急性戒烟后在不同月经期评价个体对尼古丁的生理反应差异。
   方法：年龄为18～40岁的月经正常女性入选本研究，这些受试者未使用外源性激素或精神药物治疗，吸烟每天≥5 支。参与者分为2组：无抑郁症状组（NDS；n=23）和抑郁症状组（DS；n=24）经过4天的经生物学方法证实戒烟后，参与者在卵泡期(F) 和黄体期(L) 完成两项试验。在时间0点，参与者采用尼古丁鼻腔喷剂治疗，在-1、5、10、20、30、45、60和90 min检测血压、心率和血清尼古丁含量。
   结果：参与者(n = 47) 的平均年龄为29.1±6.8 岁，平均每天吸烟12.5±5.1支。与DS组相比，NDS组在不同的月经期，收缩压、心率和血清最大尼古丁浓度差异更大（F>L）(p < 0.05).
   结论：本研究显示，性激素和抑郁症之间存在相互作用，对于无抑郁症状的女性，急性戒烟后对尼古丁的生理反应在不同月经期差异更大。本研究结果支持性激素在针对尼古丁的生理反应中具有一定作用，因此，月经期对戒烟也产生一定影响。
 

                                                                                                     (林江涛 审校)
 Nicotine Tob Res. 2012 Nov 15. [Epub ahead of print]
                                                     

Menstrual Phase and Depressive Symptoms Differences in Physiological Response to Nicotine Following Acute Smoking Abstinence.

Allen SS, Allen AM, Kotlyar M, Lunos S, Al'absi M, Hatsukami D.

Source
Department of Family Medicine & Community Health, Medical School, University of Minnesota, Minneapolis, MN.

Abstract

INTRODUCTION: Accumulating evidence has linked depressive symptoms and sex hormones to risk for relapse; however, the specific mechanisms involved in these associations remain unknown. This randomized crossover study assessed physiological response to nicotine by menstrual phase in female smokers with and without depressive symptoms following acute smoking abstinence.
METHODS: Females, ages 18-40 years with regular menstrual cycles, not on exogenous hormones or psychotropic medications, who reported smoking ≥5 cigarettes/day were enrolled. Participants were stratified into 2 groups: no depressive symptoms (NDS; n = 23) and depressive symptoms (DS; n = 24). After 4 days of biochemically verified smoking abstinence, participants completed 2 laboratory sessions in the follicular (F) and luteal (L) phases. Participants used nicotine nasal spray at Time 0, and blood pressure, heart rate, and serum nicotine were measured at Time -1, 5, 10, 20, 30, 45, 60, and 90min.
RESULTS: Participants (n = 47) were 29.1±6.8 years old and smoked an average of 12.5±5.1 cigarettes/day. The NDS group had more pronounced menstrual phase differences (F > L) in diastolic blood pressure, heart rate, and maximum concentrations of nicotine compared with the DS group (p < .05).
CONCLUSIONS: This study observed an interaction between sex hormones and depressive symptoms such that those without depressive symptoms had a greater menstrual phase difference in the physiological response to nicotine. These data offer additional support for the role of sex hormones in the physiological response to nicotine, which may play a role in menstrual phase effects on smoking cessation.

Nicotine Tob Res. 2012 Nov 15. [Epub ahead of print]