尿双酚A浓度与过敏性哮喘的相关性：来自2005-2006年国家健康和营养监测调查的结果
2012/11/19
摘要
目的：越来越多的证据表明，双酚A（BPA）会对健康产生不良影响。本试验在回顾性US人群中研究尿BPA浓度是否与过敏性哮喘相关。
方法：本次分析的数据来自于2005-2006年国家健康和营养检查调查，包括哮喘相关问题、总免疫球蛋白E（IgE）、19个过敏原特异性IgE水平和尿环境酚水平。过敏性哮喘定义为存在哮喘病史、嗜酸性粒细胞计数较高、总IgE水平较高或存在特应性。采用二元和多元logistic回归、受试者操作特征曲线、Akaike信息准则和似然比（χ2）进行相关性分析。
结果：BPA增加10倍与女性（OR=2.21，P=0.032）而非男性（OR=0.83，P=0.474）的过敏性哮喘风险增加独立相关。当采用特应性，而非总IgE来确定过敏性哮喘时，该结果同样存在（女：OR= 2.45，P=0.001；男：OR=0.83，P=0.605）。尿BPA与多种特异性过敏原致敏显著相关，该相关性呈剂量依赖性。尿BPA能独立预测过去12个月内女性而非男性哮喘发作。
结论：尿BPA与女性过敏性哮喘显著相关。
（苏楠 审校）
J Asthma. 2012 Oct;49(8):800-6. Epub 2012 Sep 10.
Association of urinary bisphenol a concentration with allergic asthma: results from the national health and nutrition examination survey 2005-2006.
Vaidya SV, Kulkarni H.
Source
Lata Medical Research Foundation , Nagpur , India.
Abstract
OBJECTIVE：Bisphenol A (BPA) is being increasingly associated with adverse health effects. Our objective was to determine whether urinary BPA concentration is associated with allergic asthma in a representative US population.
METHODS：Data for this analysis were obtained from the National Health and Nutrition Examination Survey 2005-2006 survey and included asthma-related questions, total immunoglobulin E (IgE), 19 allergen-specific IgE levels, and urinary environmental phenol measurements. Allergic asthma was defined as a history of asthma ever, high eosinophil count, and high total IgE or atopy. Association analyses included dichotomous and polychotomous logistic regression, receiver operating characteristic curves, Akaike information criterion, and likelihood ratio χ(2).
RESULTS：We found that 10-fold increase in BPA was independently associated with a higher likelihood of allergic asthma in females [odds ratio (OR) = 2.21, p = .032] but not in males (OR = 0.83, p = .474). These findings were reaffirmed when allergic asthma was defined based on atopy rather than total IgE (OR = 2.45, p = .001 in females and OR = 0.83, p = .605 in males). Urinary BPA was significantly associated with sensitization to various specific allergens in a dose-response manner. Lastly, urinary BPA independently predicted an asthma episode in the past 12 months in females but not in males.
CONCLUSIONS：Urinary BPA is significantly associated with allergic asthma in females.
J Asthma. 2012 Oct;49(8):800-6. Epub 2012 Sep 10.
目的：越来越多的证据表明，双酚A（BPA）会对健康产生不良影响。本试验在回顾性US人群中研究尿BPA浓度是否与过敏性哮喘相关。
方法：本次分析的数据来自于2005-2006年国家健康和营养检查调查，包括哮喘相关问题、总免疫球蛋白E（IgE）、19个过敏原特异性IgE水平和尿环境酚水平。过敏性哮喘定义为存在哮喘病史、嗜酸性粒细胞计数较高、总IgE水平较高或存在特应性。采用二元和多元logistic回归、受试者操作特征曲线、Akaike信息准则和似然比（χ2）进行相关性分析。
结果：BPA增加10倍与女性（OR=2.21，P=0.032）而非男性（OR=0.83，P=0.474）的过敏性哮喘风险增加独立相关。当采用特应性，而非总IgE来确定过敏性哮喘时，该结果同样存在（女：OR= 2.45，P=0.001；男：OR=0.83，P=0.605）。尿BPA与多种特异性过敏原致敏显著相关，该相关性呈剂量依赖性。尿BPA能独立预测过去12个月内女性而非男性哮喘发作。
结论：尿BPA与女性过敏性哮喘显著相关。
（苏楠 审校）
J Asthma. 2012 Oct;49(8):800-6. Epub 2012 Sep 10.
Association of urinary bisphenol a concentration with allergic asthma: results from the national health and nutrition examination survey 2005-2006.
Vaidya SV, Kulkarni H.
Source
Lata Medical Research Foundation , Nagpur , India.
Abstract
OBJECTIVE：Bisphenol A (BPA) is being increasingly associated with adverse health effects. Our objective was to determine whether urinary BPA concentration is associated with allergic asthma in a representative US population.
METHODS：Data for this analysis were obtained from the National Health and Nutrition Examination Survey 2005-2006 survey and included asthma-related questions, total immunoglobulin E (IgE), 19 allergen-specific IgE levels, and urinary environmental phenol measurements. Allergic asthma was defined as a history of asthma ever, high eosinophil count, and high total IgE or atopy. Association analyses included dichotomous and polychotomous logistic regression, receiver operating characteristic curves, Akaike information criterion, and likelihood ratio χ(2).
RESULTS：We found that 10-fold increase in BPA was independently associated with a higher likelihood of allergic asthma in females [odds ratio (OR) = 2.21, p = .032] but not in males (OR = 0.83, p = .474). These findings were reaffirmed when allergic asthma was defined based on atopy rather than total IgE (OR = 2.45, p = .001 in females and OR = 0.83, p = .605 in males). Urinary BPA was significantly associated with sensitization to various specific allergens in a dose-response manner. Lastly, urinary BPA independently predicted an asthma episode in the past 12 months in females but not in males.
CONCLUSIONS：Urinary BPA is significantly associated with allergic asthma in females.
J Asthma. 2012 Oct;49(8):800-6. Epub 2012 Sep 10.
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初级医疗机构中哮喘患者感知的哮喘控制程度与胸腹异步的相关性
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稳定哮喘患者哮喘控制和生活质量的决定因素：评价两个新的咳嗽激发试验
