急诊哮喘患儿皮质类固醇给药时间和住院时间
2012/11/19
摘要
目的:本研究旨在评价皮质类固醇给药时间与急诊哮喘患儿哮喘发作和住院时间的关系。我们认为,发病60 min内给药与平均LOS降低10分钟或更多相关。
方法:对882名患儿进行回顾性分析。到康涅狄格儿童医学中心(CCMC)急诊就诊的2-18岁哮喘急性发作患儿入选本研究。若患儿在急诊未采用皮质类固醇治疗、有明显的共患病、当前采用皮质类固醇治疗或过去7天内采用皮质类固醇治疗,则排出本研究。发病60 min内采用皮质类固醇治疗的患儿与61 min及以后治疗的患儿进行比较。主要转归为平均LOS。
结果:发病60 min及以后皮质类固醇治疗的患儿,在年龄、性别、保险和性格上无显著差异。与发病60 min以后皮质类固醇治疗的患儿相比,发病60 min内采用皮质类固醇治疗的患儿LOS下降25-分钟(95% CI: 15-35;P<0.0001)。
结论:哮喘发作1 h内给予皮质类固醇治疗与LOS下降25 min相关。由于哮喘患者就诊量很大,对于每个儿童来说,LOS下降25 min可能对急诊就诊效率产生显著影响。
(苏楠 审校)
J Asthma. 2012 Oct;49(8):862-7.
Corticosteroid timing and length of stay for children with asthma in the emergency department.
Davis SR, Burke G, Hogan E, Smith SR.
Source
University of Connecticut Health Center , Farmington, CT , USA.
Abstract
OBJECTIVE:The aim of this study was to evaluate the relationship between time of corticosteroid administration to children with asthma exacerbations in the Emergency Department (ED) and length of stay (LOS). We hypothesized administration within 60 minutes would be associated with a 10- minute or greater decrease in mean LOS.
METHODS:A retrospective chart review of 882 patients was conducted. Children between the ages of 2 and 18 years presented to the Connecticut Children’s Medical Center’s (CCMC’s) ED with an acute asthma exacerbation were included. Children were excluded if they did not receive oral corticosteroids in the ED, had significant co-morbidities, were currently taking corticosteroids, or had taken them within the past 7 days. Children receiving corticosteroids within 60 minutes of triage were compared with children receiving corticosteroids for 61 minutes or later. The primary outcome was mean LOS.
RESULTS:Children treated with corticosteroids within 60 and 61 minutes or later had similar age, gender, insurance, and disposition. Children treated with corticosteroids within 60 minutes had a 25-minute decrease in LOS compared with children treated for 61-minute or later (95% CI: 15-35), p < .0001.
CONCLUSIONS:Administering corticosteroids to pediatric asthma patients in the ED within an hour of triage is associated with a 25-minute mean decrease in LOS. With large numbers of asthma visits, a 25-minute decrease in LOS for each child could have a significant impact on patient throughput in the ED
J Asthma. 2012 Oct;49(8):862-7.
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哮喘患者能从同时采用桉树脑治疗中获益:安慰剂-对照、双盲试验
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体重过轻对哮喘控制的影响