离子水气溶胶对儿童过敏性哮喘的疗效
2012/10/11
摘要
目的：研究已经显示，离子水气溶胶对儿童过敏性哮喘有益。本研究在哮喘夏令营中进行随机对照临床试验，评价离子水气溶胶对儿童过敏性哮喘的疗效。
方法：54名过敏性哮喘患儿进行为期3周的高山哮喘夏令营，其中一半儿童每天在高山瀑布的水气溶胶下暴露1 h，而剩余儿童在对照地点暴露1 h。夏令营期间进行免疫学分析、肺功能检测和检测呼出气一氧化氮分数（FeNO），同时对2个月后的疗效进行评价。在140天内对症状进行评分。
结果：水气溶胶组所有的肺功能指标得到显著改善，对照组仅呼气峰值流速得到改善。所有患者在夏令营后，症状评分显著改善，FeNO显著下降。随访期检查显示，仅水气溶胶组的哮喘症状、肺功能和炎症得到长期改善。此外，检测了两组的IL-10和调节性T细胞（Treg细胞）。结果显示，水气溶胶组两者均显著增加。IL-13在两组中显著下降，而IL-5和嗜酸性阳离子蛋白仅在水气溶胶组下降。
结论：本研究结果证实，气候治疗可以诱导Treg细胞和降低炎症。水气溶胶对哮喘症状、肺功能和气道炎症的协同作用具有持续性。
（苏楠 审校）
J Asthma. 2012 Aug 6. [Epub ahead of print]
Effects of Ionized Waterfall Aerosol on Pediatric Allergic Asthma.
Gaisberger M, Sanović R, Dobias H, Kolarž P, Moder A, Thalhamer J, Selimović A, Huttegger I, Ritter M, Hartl A.
Source
Institute of Physiology and Pathophysiology, Paracelsus Medical University , Salzburg , Austria.
Abstract
OBJECTIVE：Ionized water aerosols have been suggested to exert beneficial health effects on pediatric allergic asthma. Their effect was evaluated in a randomized controlled clinical trial as part of a summer asthma camp.
METHODS： Asthmatic allergic children (n = 54) spent 3 weeks in an alpine asthma camp; half of the group was exposed to water aerosol of an alpine waterfall for 1 hour per day, whereas the other half spent the same time at a "control site". Immunological analysis, lung function testing, and fractional exhaled nitric oxide (FeNO) testing were performed during the stay, and sustaining effects were evaluated 2 months later. Symptom score testing was done over a period of 140 days.
RESULTS：The water aerosol group showed a significant improvement in all lung function parameters, whereas only the peak expiratory flow improved in the control group. All patients showed a significant improvement in symptom score and a significant decrease in FeNO after the camp. Only the water aerosol group exhibited a long-lasting effect on asthma symptoms, lung function, and inflammation in the follow-up examination. Induction of interleukin (IL)-10 and regulatory T (Treg) cells was measured in both groups, with a pronounced increase in the water aerosol group. IL-13 was significantly decreased in both groups, whereas IL-5 and eosinophil cationic protein were decreased only in the water aerosol group.
CONCLUSIONS：Our findings confirm the induction of Treg cells and reduction in inflammation by climate therapy. They indicate a synergistic effect of water aerosols resulting in a long-lasting beneficial effect on asthma symptoms, lung function, and airway inflammation.
J Asthma. 2012 Aug 6. [Epub ahead of print]
