儿童及其看护者对哮喘吸入治疗疗效的看法
2012/07/06
摘要
目的：虽然诸多试验对成人有关哮喘吸入治疗疗效的看法进行了研究，但儿童及其父母针对哮喘的态度、治疗的期望和疗效的看法了解较少。本试验研究哮喘儿童及其父母的看法是否与前期成人研究中报道结果存在差异。
方法：入选家庭成员中有4～11岁哮喘儿童的家庭，这些儿童近期的哮喘治疗得到了调整（开始激素吸入单药治疗[ICS]或从ICS向激素/长效β2受体激动剂联合制剂治疗[ICS/LABA]）。对父母和患儿（如果7～11岁）采用半结构化访谈进行分析。
结果：对28名父母和13名儿童进行访谈。所有采用ICS/LABA治疗的儿童，是由于哮喘控制较差，而改变了原来ICS的单药治疗。儿童哮喘对整个家庭产生显著影响，父母和儿童都希望新的治疗能改善症状，增加他们体力活动的参与，减少全科医生（GP）/医院的不定期就诊。父母和儿童均主诉治疗变化对哮喘产生正面影响，特别是从ICS向ICS/LABA变化的患儿。最常见的疗效表现为咳嗽和喘息减少、体育运动参与增加、急救用药减少。这些疗效表现导致GP/医院就诊减少以及更好的学习。
结论：虽然哮喘症状的出现能减少哮喘成人和儿童参与不同活动（学习、工作），儿童及其家长均主诉的吸入治疗疗效相同，这一点与前期成人哮喘研究类似。
（苏楠 审校）
J Asthma. 2012 Apr 10. [Epub ahead of print]
J Asthma. 2012 Apr 10. [Epub ahead of print]
Source
Department of Child Health, University Hospital of North Staffordshire , Stoke-on-Trent , UK .
Abstract
OBJECTIVE：Although well reported in adults, there is relatively little data on how children with asthma and their parents describe their attitudes to the disease, expectations of therapy, and perception of treatment benefit. We investigated this to determine if they differed from reports by adults with asthma.
METHODS：We recruited families with an asthmatic child (4-11 years) who had recently been prescribed a change in treatment [starting inhaled corticosteroid monotherapy (ICS) or changing from ICS to inhaled corticosteroid/long-acting β(2)-agonist combination therapy (ICS/LABA)]. Semi-structured interviews were conducted with the parents and the children if aged 7-11 years.
RESULTS：We interviewed 28 parents and 13 children. All children on ICS/LABA had been changed from ICS monotherapy because of poor asthma control. Pediatric asthma had a significant impact on the whole family and both parents and children hoped the new medication would improve symptoms, increase their participation in physical activities, and decrease unscheduled visits to the GP (General Practitioner)/hospital. Positive effects of treatment change were reported by both parents and children, particularly in those changing from ICS to ICS/LABA. The most commonly reported benefits were reduced cough and wheeze, increased participation in sport or play activities, and reduced rescue medication use. These effects resulted in fewer visits to the GP/hospital and better attendance at school.
CONCLUSIONS：While asthma symptoms prevent adults and children from participating in different types of activities (e.g., school, employment), children and their parents report the same benefits as previously reported in adults with asthma.
J Asthma. 2012 Apr 10. [Epub ahead of print]
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儿童及其看护者对哮喘吸入治疗疗效的看法
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优秀运动员中运动诱发哮喘的机制和处理
