生命早期肺功能和1岁内的呼吸病转归
2012/07/06
摘要
生命早期肺功能异常与儿童期喘息相关，然而有关其与咳嗽的关系尚不清楚。本研究在对潜在的危险因素校正后，分析生命早期肺功能与1岁内喘息和咳嗽的相关性。婴儿来自于荷兰Leidsche Rijn喘息疾病研究（WHISTLE）。在出生后2个月内即开始检测肺功能。产前和围生期因素、一般特征和人体测量学通过问卷调查进行评价。通过每日问卷调查对呼吸道症状相关的随访数据进行评价。836名婴儿获得有效的肺功能检测数据，并完成1岁内有关呼吸道症状的随访。多变量泊松分析显示，呼吸阻抗（Rrs）和时间常量（τrs）较高与1岁内喘息和咳嗽发生风险增加相关。呼吸道顺应性（Crs）较高与喘息和咳嗽风险下降相关。出生后不久检测的Rrs、Crs和τrs与1岁内喘息和咳嗽独立相关。由于与喘息和咳嗽的相关性存在差异，因此喘息和咳嗽应该是两个不同的疾病。
生命早期肺功能异常与儿童期喘息相关，然而有关其与咳嗽的关系尚不清楚。本研究在对潜在的危险因素校正后，分析生命早期肺功能与1岁内喘息和咳嗽的相关性。婴儿来自于荷兰Leidsche Rijn喘息疾病研究（WHISTLE）。在出生后2个月内即开始检测肺功能。产前和围生期因素、一般特征和人体测量学通过问卷调查进行评价。通过每日问卷调查对呼吸道症状相关的随访数据进行评价。836名婴儿获得有效的肺功能检测数据，并完成1岁内有关呼吸道症状的随访。多变量泊松分析显示，呼吸阻抗（Rrs）和时间常量（τrs）较高与1岁内喘息和咳嗽发生风险增加相关。呼吸道顺应性（Crs）较高与喘息和咳嗽风险下降相关。出生后不久检测的Rrs、Crs和τrs与1岁内喘息和咳嗽独立相关。由于与喘息和咳嗽的相关性存在差异，因此喘息和咳嗽应该是两个不同的疾病。
（陈欣 审校）
Eur Respir J. 2012 Apr 10. [Epub ahead of print]
Eur Respir J. 2012 Apr 10. [Epub ahead of print]
van Putte-Katier N, van der Gugten AC, Uiterwaal CS, de Jong BM, Numans ME, Kimpen JL, Verheij TJ, van der Ent CK; for the WHISTLER study group.
Source
University Medical Center Utrecht, Utrecht, The Netherlands.
Abstract
Abnormal early life lung function is related to wheezing in childhood, however data on the association with cough are not available. We determined the relation between early life lung function and wheeze and cough during the first year of life, adjusted for other possible risk factors. Infants were participants of the Wheezing Illnesses Study Leidsche Rijn (WHISTLER). Lung function measurements were performed before the age of 2 months. Information on pre- and perinatal factors, general characteristics and anthropometrics were assessed by questionnaires. Follow-up data on respiratory symptoms were assessed by daily questionnaires.836 infants had valid lung function measurements and complete follow-up data for respiratory symptoms at one year of age. Multivariable Poisson analysis showed that higher values of respiratory resistance (Rrs) and time constant (τrs) were associated with an increased risk for wheeze and cough during the first year of life. Higher values of respiratory compliance (Crs) were associated with a decreased risk for wheeze and cough. Rrs, Crs and τrs measured shortly after birth were independently associated with wheeze and cough during the first year of life. As the strength of the relations were different for wheeze and cough, they should be used as two separate entities.
Eur Respir J. 2012 Apr 10. [Epub ahead of print]
上一篇：
空气指标预测小学儿童哮喘发作：宾夕法尼亚州每日环境调查联合学校卫生监督的研究
下一篇：
初级保健机构COPD和哮喘鉴别诊断的困难
