每天真空吸尘器清理床垫能显著减少屋尘螨过敏原、细菌内毒素和真菌β-葡聚糖
2012/04/06
背景和目的:特应性患者常常被要求用外罩将床垫严实地包裹,但这些外罩并不便宜。本研究旨在评价每天以真空吸尘器清理床垫是否能显著减少屋尘螨过敏原、细菌内毒素和真菌β-葡聚糖。
方法:20名志愿者每天对其床垫进行真空吸尘器清理,连续8周。每2周1次收集屋内灰尘,采用两种单克隆抗体的ELISA检测屋尘螨过敏原(Der p 1和Der f 1),采用鲎试剂裂解液动力学分析内毒素和β-葡聚糖。结果表示为几何平均值和95%可信区间。
结果:总的屋尘螨过敏原(Der p 1 + Der f 1)显著下降(从4.07 μg [2.44-6.79]下降至8周时的0.42 μg [0.21-0.81])。总内毒素和β-葡聚糖也显著下降(内毒素从13.6 EU [8.6-21.4]下降至3.4 EU[2.3-5.0];β-葡聚糖从94.4 μg [57.1-156.2]下降至19.7 μg [10.2-37.9],P>.0001)。每天对床垫真空清理,8周后,总屋尘螨过敏原、内毒素和β-葡聚糖分别下降了85.1%(80.1-90.1)、71.0%(70.4-81.0)和75.7% (70.4-81.0)。屋内灰尘总体下降77.7%(70.8-84.7)。
结论:每日真空清理床垫能显著减少屋尘螨过敏原、内毒素和β-葡聚糖。这对于特应性患者来说是一个减少屋内尘螨过敏原和微生物污染物接触的比较实际和便宜的方法。
(林江涛 审校)
J Asthma. 2012 Mar;49(2):139-43.
Daily Vacuuming of Mattresses Significantly Reduces House Dust Mite Allergens, Bacterial Endotoxin, and Fungal β-Glucan.
Wu FF, Wu MW, Pierse N, Crane J, Siebers R.
Source
Show Chwan Memorial Hospital , Changhua City , Taiwan.
Abstract
BACKGROUND AND AIMS:Atopic patients are advised to cover their mattresses with occlusive coverings; however, these are not cheap. We investigated whether daily vacuum cleaning of mattresses significantly reduces content of house dust mite allergens, bacterial endotoxin, and fungal β-glucan.
METHODS:Twenty volunteers vacuumed their mattress daily for 8 weeks. Dust samples collected at two weekly intervals were analyzed for house dust mite allergens (Der p 1 and Der f 1) by double monoclonal antibody ELISA and for endotoxin and β-glucan by the Limulus amoebocyte lysate kinetic assay. Results are presented as geometric means with 95% confidence interval (CI).
RESULTS:Total house dust mite allergens (Der p 1 + Der f 1) significantly reduced from a geometric mean (95% CI) of 4.07 μg (2.44-6.79) at the start to 0.42 μg (0.21-0.81) at week 8. Total endotoxin and β-glucan were also significantly reduced from 13.6 EU (8.6-21.4) to 3.4 EU (2.3-5.0) and from 94.4 μg (57.1-156.2) to 19.7 μg (10.2-37.9), respectively (p for trend >.0001). Percentage reductions in total house dust mite allergens, endotoxin, and β-glucan after 8 weeks of daily vacuum cleaning were 85.1% (80.1-90.1), 71.0% (70.4-81.0), and 75.7% (70.4-81.0), respectively. This was mainly due to a 77.7% (70.8-84.7) reduction in total dust.
CONCLUSION:Daily vacuum cleaning of mattresses over time significantly reduces house dust mite allergens, endotoxin, and β-glucan. This gives atopic patients a practical and cheaper alternative to reduce their exposure to indoor house dust mite allergens and microbial bio-contaminants.
J Asthma. 2012 Mar;49(2):139-43.
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