母乳喂养预防6岁内儿童现患哮喘
2012/02/29
目的:研究母乳喂养对2~6岁儿童喘息和现患哮喘的影响。
研究设计:1105名婴儿入选本项新西兰前瞻性出生队列研究。出生时及3、6和15个月时,通过问卷调查的形式,收集有关婴儿喂养形式的详细信息。计算各喂养形式持续的时间。2、3、4、5和6岁时收集有关喘息和现患哮喘的相关信息。对混杂因素校正和未校正后,采用Logistic回归模型分析母乳喂养与喘息和/或哮喘的关系。
结果:在经混杂因素校正后,每个月单独母乳喂养与2~6岁时当前哮喘显著下降相关(P<0.03)。2、3和4岁时现患哮喘也与每个月母乳喂养下降相关(P<0.005)。对于特应症儿童,单独母乳喂养≥3个月能分别降低4、5和6岁时62%、55%和59%的现患哮喘患病风险。
结论:母乳喂养,特别是单独母乳喂养,能预防6岁内的现患哮喘发生。虽然单独母乳喂养能降低6岁内现患哮喘患病风险,该保护程度在特应症儿童3岁以后更为明显。
(刘国梁 审校)
J Pediatr. 2012 Jan 28. [Epub ahead of print]
Breastfeeding Protects against Current Asthma up to 6 Years of Age.
Silvers KM, Frampton CM, Wickens K, Pattemore PK, Ingham T, Fishwick D, Crane J, Ian Town G, Epton MJ; New Zealand Asthma and Allergy Cohort Study Group.
Source
Department of Paediatrics, School of Medicine and Health Sciences, University of Otago Christchurch, Christchurch, New Zealand.
Abstract
OBJECTIVE: To investigate the effects of breastfeeding on wheezing and current asthma in children 2 to 6 years of age.
STUDY DESIGN: Infants (n=1105) were enrolled in a prospective birth cohort in New Zealand. Detailed information about infant feeding was collected using questionnaires administered at birth and at 3, 6, and 15 months. From this, durations of exclusive and any breastfeeding were calculated. Information about wheezing and current asthma was collected at 2, 3, 4, 5, and 6 years. Logistic regression was used to model associations between breastfeeding and outcomes with and without adjustment for confounders.
RESULTS: After adjustment for confounders, each month of exclusive breastfeeding was associated with significant reductions in current asthma from 2 to 6 years (all, P<.03). Current asthma at 2, 3, and 4 years was also reduced by each month of any breastfeeding (all, P<.005). In atopic children, exclusive breastfeeding for ≥3 months reduced current asthma at ages 4, 5, and 6 by 62%, 55%, and 59%, respectively.
CONCLUSION: Breastfeeding, particularly exclusive breastfeeding, protects against current asthma up to 6 years. Although exclusive breastfeeding reduced risk of current asthma in all children to age 6, the degree of protection beyond 3 years was more pronounced in atopic children.
J Pediatr. 2012 Jan 28. [Epub ahead of print]
上一篇:
宿主和环境因素对婴儿喘息严重程度的影响:来自PARIS出生队列研究的结果
下一篇:
交通相关的污染物和儿童喘息