花粉能增加沙尘对成人哮喘患者症状的影响
2011/12/26
背景:东亚沙尘风暴主要见于春季,又称之为亚洲沙尘暴(ADS)。本试验旨在日本成人哮喘患者中研究花粉和ADS与哮喘症状的关系。
方法:通过电话调查方式,研究2009年2、3和12月份ADS时哮喘患者的上和下呼吸道、眼睛和皮肤症状。检测2~5月的呼气峰值流量(PEF)。
结果:在2、3月和12月分别对106、101和103名患者进行了调查。2月和3月,日本雪松和/或丝柏花粉同样在ADS时空气中出现,但12月调查中未见有花粉。2、3月和12月分别有20.8%、33.7%和16.5%的患者出现上和下呼吸道、眼睛或皮肤症状的恶化。3月出现症状恶化较2月和12月更为常见。2名患者在3月份ADS时,因为哮喘恶化而需要急诊就医,但3个时间段未见患者住院治疗。ADS与平时,每日早晨PEF/个人最佳PEF比例无显著差异。然而,有上和/或下呼吸道症状的患者,每日早晨PEF/个人最佳PEF比例与大气中颗粒物水平相关,但与花粉和其他的空气污染物水平无关。
结论:花粉能增加成人哮喘患者的症状,但ADS本身也能导致哮喘患者症状和肺功能的恶化。
(刘国梁 审校)
Allergol Int. 2011 Nov;60(4):517-24.
Pollen augments the influence of desert dust on symptoms of adult asthma patients.
Watanabe M, Igishi T, Burioka N, Yamasaki A, Kurai J, Takeuchi H, Sako T, Yoshida A, Yoneda K, Fukuoka Y, Nakamoto M, Hasegawa Y, Chikumi H, Matsumoto S, Minato S, Horasaki K, Shimizu E.
Source
Department of Respirology and Rheumatology, Faculty of Medicine, Tottori University, Tottori, Japan.
Abstract
BACKGROUND: East Asian desert dust storms that occur during mainly spring are called Asian dust storms (ADS). Our objective was to study the association of pollen and ADS with symptoms of adult asthma patients in Japan.
METHODS: We designed a telephone survey to investigate the upper and lower respiratory, ocular, and skin symptoms of asthma patients during ADS in February, March, and December on 2009. Peak expiratory flow (PEF) was also measured from February to May.
RESULTS: We surveyed 106 patients in February, 101 patients in March, and 103 patients in December. In February and March, Japanese cedar and/or cypress pollen was also in the atmosphere during ADS, but no pollen was identified during December survey. Worsening of upper or lower respiratory, ocular, or skin symptoms was noted by 20.8% of patients in February, 33.7% in March, and 16.5% in December. Worsening of symptoms was significantly more common in March than in February or December. Two patients needed emergency treatment for exacerbation during ADS in March, but no patient needed hospitalization in any period. There was no significant difference of the daily morning PEF/personal best PEF ratio between ADS days and control days. However, in patients with worsening of upper and/or lower respiratory tract symptoms, the daily morning PEF/personal best ratio was significantly associated with the atmospheric level of particulate matter, but not with levels of pollen or other air pollutants.
CONCLUSIONS: Pollen augmented symptoms in adult asthma patients, but ADS on its own also were able to aggravate symptoms and pulmonary function.
Allergol Int. 2011 Nov;60(4):517-24.
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微生物与哮喘:未意识到的细胞和分子联系
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