抗氧化食品补充剂、防腐剂、着色剂在过敏症和哮喘发病中的作用
2011/11/22
摘要
过去几十年里,过敏症和哮喘的发病率呈现了显著上升的趋势。导致该现象的原因尚不完全清楚,但生活方式和生活习惯的改变是大家广泛讨论的主要原因。其中之一就是过于清洁的环境,这增加了个体对过敏性反应的易感性。此外,饮食中的一些添加成分如防腐剂和着色剂有增多趋势,这也是导致发病率增加的一个原因。体外实验显示,在新鲜分离的人外周血单核细胞中,有一些抗氧化剂(如维生素C和维生素E)和食品防腐剂和着色剂对Th1免疫活化级联反应具有明显的抑制作用。从这些结果可以得出,抗氧化复合物与促炎级联反应之间存在的相互作用,干扰了重要的信号传导途径(如核因子-κB)。虽然这些结果来自于体外实验,但结果显示,具有抗炎特性的复合物,能将Th1-Th2型免疫平衡转换为Th2型免疫。本综述主要讨论了食物补充剂中的抗氧化剂、防腐剂和着色剂在西方国家哮喘和过敏症发病增加中的作用。
(苏楠 审校)
Int Arch Allergy Immunol. 2011 Oct 5;157(2):113-124. [Epub ahead of print]
Potential Role of Antioxidant Food Supplements, Preservatives and Colorants in the Pathogenesis of Allergy and Asthma.
Zaknun D, Schroecksnadel S, Kurz K, Fuchs D.
Source
Division of Nutrition and Lipid Metabolism Disorders, Department of Pediatrics, University Hospital of Vienna, Vienna, Austria.
Abstract
A significant increase in the incidence of allergy and asthma has been observed during the past decades. The background of this phenomenon has not been well explained, but changes in lifestyle and habits are heavily discussed as contributing factors. Among these is a too clean environment, which may predispose individuals to increased sensitivity to allergic responses. Also the increase in dietary supplements including preservatives and colorants may contribute to this. In vitro, we and others have shown in freshly isolated human peripheral blood mononuclear cells that antioxidant compounds like vitamins C and E as well as food preservatives and colorants exert significant suppressive effects on the Th1 immune activation cascade. The effects observed may be based on the interaction of antioxidant compounds with proinflammatory cascades involving important signal transduction elements such as nuclear factor-κB. Although only obtained in vitro, these results show an anti-inflammatory property of compounds which could shift the Th1-Th2-type immune balance towards Th2-type immunity. This review article discusses the potential role of increased use of antioxidant food supplements as well as preservatives and colorants in the increase in allergy and asthma in the Western world.
Int Arch Allergy Immunol. 2011 Oct 5;157(2):113-124. [Epub ahead of print]
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维生素D缺乏对小儿哮喘的强预测作用
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重度哮喘患者免疫反应性胸腺基质淋巴细胞生成素表达增加