小儿哮喘急性加重期呼吸道病毒的评估
2011/11/22
摘要
目的：常见的上呼吸道病毒常导致儿童和成人哮喘病情恶化，也是哮喘加重的重要原因。前瞻性流行病学研究显示，高达80%的小儿哮喘加重与上呼吸道病毒感染有关。
材料与方法：104例年龄为3～17岁的哮喘儿童入选本研究。这些患儿于2009年至2010年间因哮喘加重在我院门诊接受治疗。在急性发作时获取所有患者的鼻咽和鼻拭子进行分析。对照组入选31例受试者。采用实时多重PCR法检测样本的病毒性呼吸道病原体。按照是否存在呼吸道病原体以及与哮喘加重有关的因素对患者进行比较。
结果：急性加重组有53.8%的患者检测到致病性呼吸道病毒。最常见的病毒是鼻病毒。将哮喘加重的严重程度、患者对全身类固醇激素治疗的需求以及住院率，在有和无病毒感染的急性哮喘加重患者之间进行比较。结果显示两组间无显著差异。
结论：虽然病毒性上呼吸道感染是哮喘加重的常见原因，但是哮喘加重的严重程度可能与呼吸道病毒感染无关。
（林江涛 审校）
J Asthma. 2011 Sep 2. [Epub ahead of print]
Evaluation of Respiratory Viral Pathogens in Acute Asthma Exacerbations during Childhood.
Ozcan C, Toyran M, Civelek E, Erkoçoğlu M, Altaş AB, Albayrak N, Korukluoğlu G, Kocabaş CN.
Source
Department of Pediatric Allergy, Ankara Children’s Hematology Oncology Education and Research Hospital , Ankara , Turkey.
Abstract
OBJECTIVE：Common upper respiratory tract viruses are the most frequent and important causes of asthma exacerbations in both children and adults. Prospective epidemiologic studies report that up to 80% of childhood exacerbations are associated with viral upper respiratory tract infections.
MATERIALS AND METHODS：The study group consisted of 104 children with asthma aged 3-17 years who received treatment for asthma exacerbations in our clinic between September 2009 and 2010. Nasopharyngeal and nasal swabs were obtained from all patients during an acute attack, and from the control group (31 subjects). These specimens were investigated for the presence of viral respiratory pathogens using a real-time multiplex PCR method. The patients were compared for the presence of respiratory pathogens and factors related to the severity of the asthma exacerbation.
RESULTS：A pathogenic respiratory virus was detected in 53.8% of patients in the acute exacerbation group. The most commonly encountered viral agent was Rhinovirus (35.6%). Patients who had an acute exacerbation with or without a detectable viral pathogen were compared according to the severity of the exacerbation, the need for systemic steroids, and hospitalization rates. No statistically significant difference was found.
CONCLUSION：Although viral upper respiratory tract infections are the most common cause of asthma exacerbations, the severity level of the exacerbation seems to be independent of whether a respiratory virus has been detected.
J Asthma. 2011 Sep 2. [Epub ahead of print]
目的：常见的上呼吸道病毒常导致儿童和成人哮喘病情恶化，也是哮喘加重的重要原因。前瞻性流行病学研究显示，高达80%的小儿哮喘加重与上呼吸道病毒感染有关。
材料与方法：104例年龄为3～17岁的哮喘儿童入选本研究。这些患儿于2009年至2010年间因哮喘加重在我院门诊接受治疗。在急性发作时获取所有患者的鼻咽和鼻拭子进行分析。对照组入选31例受试者。采用实时多重PCR法检测样本的病毒性呼吸道病原体。按照是否存在呼吸道病原体以及与哮喘加重有关的因素对患者进行比较。
结果：急性加重组有53.8%的患者检测到致病性呼吸道病毒。最常见的病毒是鼻病毒。将哮喘加重的严重程度、患者对全身类固醇激素治疗的需求以及住院率，在有和无病毒感染的急性哮喘加重患者之间进行比较。结果显示两组间无显著差异。
结论：虽然病毒性上呼吸道感染是哮喘加重的常见原因，但是哮喘加重的严重程度可能与呼吸道病毒感染无关。
（林江涛 审校）
J Asthma. 2011 Sep 2. [Epub ahead of print]
Evaluation of Respiratory Viral Pathogens in Acute Asthma Exacerbations during Childhood.
Ozcan C, Toyran M, Civelek E, Erkoçoğlu M, Altaş AB, Albayrak N, Korukluoğlu G, Kocabaş CN.
Source
Department of Pediatric Allergy, Ankara Children’s Hematology Oncology Education and Research Hospital , Ankara , Turkey.
Abstract
OBJECTIVE：Common upper respiratory tract viruses are the most frequent and important causes of asthma exacerbations in both children and adults. Prospective epidemiologic studies report that up to 80% of childhood exacerbations are associated with viral upper respiratory tract infections.
MATERIALS AND METHODS：The study group consisted of 104 children with asthma aged 3-17 years who received treatment for asthma exacerbations in our clinic between September 2009 and 2010. Nasopharyngeal and nasal swabs were obtained from all patients during an acute attack, and from the control group (31 subjects). These specimens were investigated for the presence of viral respiratory pathogens using a real-time multiplex PCR method. The patients were compared for the presence of respiratory pathogens and factors related to the severity of the asthma exacerbation.
RESULTS：A pathogenic respiratory virus was detected in 53.8% of patients in the acute exacerbation group. The most commonly encountered viral agent was Rhinovirus (35.6%). Patients who had an acute exacerbation with or without a detectable viral pathogen were compared according to the severity of the exacerbation, the need for systemic steroids, and hospitalization rates. No statistically significant difference was found.
CONCLUSION：Although viral upper respiratory tract infections are the most common cause of asthma exacerbations, the severity level of the exacerbation seems to be independent of whether a respiratory virus has been detected.
J Asthma. 2011 Sep 2. [Epub ahead of print]
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体重指数与喘息及哮喘成U形相关且与湿疹及鼻结膜炎无关——琉球儿童健康研究
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务农和非务农农村人群新发哮喘情况及环境与职业对哮喘的影响
