咳嗽的治疗：我们还缺什么？
2011/10/13
摘要
虽然对咳嗽进行了深入的研究，但仍然存在着一些不足之处。这些不足之处主要有：缺少针对咳嗽的随机对照研究；研究中并未采用较强的咳嗽转归检测指标；在研究中和指南中目标人群的定义较差；缺少安全和有效的治疗；在明确致病因素上存在困难；针对咳嗽主要病因的治疗，目前尚缺少预测治疗反应的预测因素。在关注改善咳嗽患者生活的咳嗽治疗中，需要通过系统性方法来阐明目前的缺陷，包括更好的药物治疗、高质量的研究、优化的多学科指南和宣教（医疗专业人员和患者）。为获得咳嗽治疗的新方法，需要不断增进对人类咳嗽过程的了解（不仅仅在动物模型中）。开发新的无明显副作用的咳嗽治疗还有很长的路要走。
（陈欣 审校）
Expert Rev Respir Med. 2011 Aug;5(4):503-13.
Therapy for cough: where does it fall short?
Chang AB.
Source
Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia and Queensland Children’s Respiratory Centre and Queensland Children’s Medical Research Institute, Royal Children’s Hospital, Brisbane, QLD 4029, Australia. annechang@ausdoctors.net.
Abstract
Studies on cough have come a long way but many shortfalls still exist. These shortfalls can be attributed to: the lack of randomized controlled studies with a focus on cough; studies not using robust cough outcome measures, poor definition of target groups in studies and guidelines, the lack of safe and efficacious treatments; difficulty in defining etiological factors, and the lack of data on the predictors of response to therapies for cough dominant etiologies. Addressing shortfalls in cough therapy that focuses on improving the lives of people with cough requires a systematic approach that includes better medications, high quality studies, improved multidisciplinary guidelines and education (of both health professionals and patients). To achieve new cough therapeutics requires an improved understanding of cough in humans (i.e., not just in animals). Development of new medications without substantial adverse events is long awaited for cough.
Expert Rev Respir Med. 2011 Aug;5(4):503-13.
虽然对咳嗽进行了深入的研究，但仍然存在着一些不足之处。这些不足之处主要有：缺少针对咳嗽的随机对照研究；研究中并未采用较强的咳嗽转归检测指标；在研究中和指南中目标人群的定义较差；缺少安全和有效的治疗；在明确致病因素上存在困难；针对咳嗽主要病因的治疗，目前尚缺少预测治疗反应的预测因素。在关注改善咳嗽患者生活的咳嗽治疗中，需要通过系统性方法来阐明目前的缺陷，包括更好的药物治疗、高质量的研究、优化的多学科指南和宣教（医疗专业人员和患者）。为获得咳嗽治疗的新方法，需要不断增进对人类咳嗽过程的了解（不仅仅在动物模型中）。开发新的无明显副作用的咳嗽治疗还有很长的路要走。
（陈欣 审校）
Expert Rev Respir Med. 2011 Aug;5(4):503-13.
Therapy for cough: where does it fall short?
Chang AB.
Source
Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia and Queensland Children’s Respiratory Centre and Queensland Children’s Medical Research Institute, Royal Children’s Hospital, Brisbane, QLD 4029, Australia. annechang@ausdoctors.net.
Abstract
Studies on cough have come a long way but many shortfalls still exist. These shortfalls can be attributed to: the lack of randomized controlled studies with a focus on cough; studies not using robust cough outcome measures, poor definition of target groups in studies and guidelines, the lack of safe and efficacious treatments; difficulty in defining etiological factors, and the lack of data on the predictors of response to therapies for cough dominant etiologies. Addressing shortfalls in cough therapy that focuses on improving the lives of people with cough requires a systematic approach that includes better medications, high quality studies, improved multidisciplinary guidelines and education (of both health professionals and patients). To achieve new cough therapeutics requires an improved understanding of cough in humans (i.e., not just in animals). Development of new medications without substantial adverse events is long awaited for cough.
Expert Rev Respir Med. 2011 Aug;5(4):503-13.
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持续性咳嗽患者的血浆物质P水平
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根据急性咳嗽/下呼吸道感染患者痰变色情况给予抗生素治疗
