血清脂氧素A4水平不能预测幼儿罹患急性细支气管炎后是否发生哮喘
2011/10/13
摘要
背景：婴幼儿中急性细支气管炎常常导致喘息发作，但是两者的相关性仍不清楚。我们认为血清脂氧素（Lipoxin ）A4水平可以作为急性细支气管炎幼儿后期哮喘发作的早期预测性生物标志物。
方法：69名儿童入选，并分为3组：47名年龄小于24个月的急性细支气管炎患儿作为实验组（组1），11名2~24个月患病毒性急性胃肠炎的儿童作为非过敏性对照组（组2），11名年龄大于24个月、经医生诊断为哮喘恶化的患儿作为哮喘对照组（组3）。检测白细胞计数、嗜酸性粒细胞计数、血清C反应蛋白、IL-4、IL-5、前列腺素E2、肿瘤坏死因子a和脂氧素A4。
结果：平均血清脂氧素A4在组1、组2和组3分别为0.043±0.028、0.054±0.015和0.0510.031 ng/ml。 t检验显示，组1与组2和组3之间无显著差异，但组2与组3之间存在显著差异(p=0.0392)。回归模型中，所有患儿的血清脂氧素A4水平与患者年龄、女性、白细胞计数、IL-5水平成正相关，而哮喘患儿与其他两组相比，具有较低的脂氧素A4。
结论：血清脂氧素A4水平不能作为急性细支气管幼儿早期预测哮喘的标志物。
(林江涛 审校)
J Asthma. 2011 Aug;48(6):576-80. Epub 2011 Jun 15.
背景：婴幼儿中急性细支气管炎常常导致喘息发作，但是两者的相关性仍不清楚。我们认为血清脂氧素（Lipoxin ）A4水平可以作为急性细支气管炎幼儿后期哮喘发作的早期预测性生物标志物。
方法：69名儿童入选，并分为3组：47名年龄小于24个月的急性细支气管炎患儿作为实验组（组1），11名2~24个月患病毒性急性胃肠炎的儿童作为非过敏性对照组（组2），11名年龄大于24个月、经医生诊断为哮喘恶化的患儿作为哮喘对照组（组3）。检测白细胞计数、嗜酸性粒细胞计数、血清C反应蛋白、IL-4、IL-5、前列腺素E2、肿瘤坏死因子a和脂氧素A4。
结果：平均血清脂氧素A4在组1、组2和组3分别为0.043±0.028、0.054±0.015和0.0510.031 ng/ml。 t检验显示，组1与组2和组3之间无显著差异，但组2与组3之间存在显著差异(p=0.0392)。回归模型中，所有患儿的血清脂氧素A4水平与患者年龄、女性、白细胞计数、IL-5水平成正相关，而哮喘患儿与其他两组相比，具有较低的脂氧素A4。
结论：血清脂氧素A4水平不能作为急性细支气管幼儿早期预测哮喘的标志物。
(林江涛 审校)
J Asthma. 2011 Aug;48(6):576-80. Epub 2011 Jun 15.
Source
Department of Pediatrics, Taipei City Hospital , Yangming Branch , Taiwan .
Department of Pediatrics, Taipei City Hospital , Yangming Branch , Taiwan .
Abstract
BACKGROUND： Acute bronchiolitis frequently causes wheezing in infants and young children, although its relationship to asthma remains unclear. We hypothesized that serum lipoxin A(4) levels may be used as an early predictive biomarker of subsequent asthma in young children with acute bronchiolitis.
METHODS： We recruited 69 children who were divided into 3 groups: 47 children younger than 24 months with acute bronchiolitis as an experimental group (Group 1); 11 children aged 2-24 months with viral acute gastroenteritis as a non-allergic control group (Group 2); and 11 children older than 24 months with physician-diagnosed asthma exacerbations as an asthma control group (Group 3). We determined white blood cell counts, eosinophil counts, and serum levels of C-reactive protein, interleukin-4, interleukin-5, prostaglandin E(2), tumor necrosis factor-alpha, and lipoxin A(4). RESULTS： The mean serum levels of lipoxin A(4) in the groups with acute bronchiolitis (1), acute gastroenteritis (2), and asthma (3) were 0.0430.028, 0.0540.015, and 0.0510.031 ng/ml, respectively. When compared by t-tests, there were no significant differences between Groups 1 and 2, or Groups 1 and 3 (p0.05), despite a significant difference between Groups 2 and 3 (p=0.0392). In a final regression model, serum lipoxin A(4) levels were positively correlated with age, female gender, white blood cell counts, and interleukin-5 levels in all patients, while asthma patients had lower serum lipoxin A(4) levels compared to the other two groups.
CONCLUSION： Serum levels of lipoxin A(4) cannot be used as an early predictive diagnostic marker for asthma in young children with acute bronchiolitis.
BACKGROUND： Acute bronchiolitis frequently causes wheezing in infants and young children, although its relationship to asthma remains unclear. We hypothesized that serum lipoxin A(4) levels may be used as an early predictive biomarker of subsequent asthma in young children with acute bronchiolitis.
METHODS： We recruited 69 children who were divided into 3 groups: 47 children younger than 24 months with acute bronchiolitis as an experimental group (Group 1); 11 children aged 2-24 months with viral acute gastroenteritis as a non-allergic control group (Group 2); and 11 children older than 24 months with physician-diagnosed asthma exacerbations as an asthma control group (Group 3). We determined white blood cell counts, eosinophil counts, and serum levels of C-reactive protein, interleukin-4, interleukin-5, prostaglandin E(2), tumor necrosis factor-alpha, and lipoxin A(4). RESULTS： The mean serum levels of lipoxin A(4) in the groups with acute bronchiolitis (1), acute gastroenteritis (2), and asthma (3) were 0.0430.028, 0.0540.015, and 0.0510.031 ng/ml, respectively. When compared by t-tests, there were no significant differences between Groups 1 and 2, or Groups 1 and 3 (p0.05), despite a significant difference between Groups 2 and 3 (p=0.0392). In a final regression model, serum lipoxin A(4) levels were positively correlated with age, female gender, white blood cell counts, and interleukin-5 levels in all patients, while asthma patients had lower serum lipoxin A(4) levels compared to the other two groups.
CONCLUSION： Serum levels of lipoxin A(4) cannot be used as an early predictive diagnostic marker for asthma in young children with acute bronchiolitis.
J Asthma. 2011 Aug;48(6):576-80. Epub 2011 Jun 15.
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