健康相关生活质量评价对可疑重度哮喘患儿的临床益处
2011/07/06
摘要
目的:研究健康相关生活质量和哮喘控制测试在评价可疑重度哮喘患者哮喘控制中的作用,鉴别与这些检测相关的临床特征。
方法:在此项多中心横断面研究中,入选93名儿童,其中有54名为可疑重度哮喘患儿和39名年龄匹配的哮喘控制患儿。受试者完成儿童哮喘生活质量问卷调查和标准的健康问卷调查和哮喘控制测试。客观检测指标为呼出气一氧化氮、特异性致敏、肺功能和乙酰甲胆碱诱发的支气管高反应性。
结果:可疑重度哮喘患儿健康相关生活质量显著下降(5.4 vs 6.7, p£0.001),特别是女童(5.1 vs 5.6 男童, P=0.02)。与哮喘控制患儿相比,可疑重度哮喘患儿的哮喘控制测试评分也较低(17 vs 23, p£0.001)。健康相关生活质量评分<6.2能鉴别可疑重度哮喘患儿和哮喘控制患儿,敏感性和特异性分别为85%和97%,而要鉴别两者的哮喘控制测试评分为<20(79%的敏感性和94%的特异性)。客观检测指标和其他的临床特征基本和健康相关生活质量评分和哮喘控制测试评分无关。
结论:健康相关生活质量和哮喘控制测试两种主观检测手段,均可用于鉴别可疑重度哮喘患儿和哮喘控制患儿。
(刘国梁 审校)
Acta Paediatr. 2011 May 19. doi: 10.1111/j.1651-2227.2011.02359.x. [Epub ahead of print]
The clinical benefit of evaluating health-related-quality-of-life in children with problematic severe asthma.
Nordlund B, Konradsen JR, Pedroletti C, Kull I, Hedlin G.
Source
Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm Sweden Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Abstract
AIM: To evaluate health-related-quality-of-life and the asthma control test in children with problematic severe asthma and controlled asthma, and to identify whether clinical characteristics show correlations with these measurements. METHODS: This multicentre cross-sectional study included 93 children in total, 54 with problematic severe asthma and 39 age-matched with controlled asthma. Subjects completed the Paediatric Asthma Quality-of-Life Questionnaire as well as a standardised health questionnaire and the asthma control test. Objective measurements of exhaled nitric oxide, specific sensitisation, pulmonary function and bronchial hyperresponsiveness to methacholine were also performed. RESULTS: Health-related-quality-of-life was reduced in children with problematic severe asthma (5.4 versus 6.7, p=<0.001), particularly for girls (5.1 versus 5.6 for boys, p=0.02), and asthma control test scores were also lower (17 versus 23, p=<0.001) compared to subjects with controlled asthma. A health-related-quality-of-life score < 6.2 discriminated problematic severe asthma from controlled asthma with 85% sensitivity and 97% specificity, as did the asthma control test score < 20 (79% sensitivity and 94% specificity). Objective measures and other clinical characteristics were weakly associated with health-related-quality-of-life or asthma control test score.
CONCLUSION: Subjective measurements of health-related-quality-of-life and asthma control are both equally useful in differentiating children with problematic severe asthma from those with controlled asthma
Acta Paediatr. 2011 May 19. doi: 10.1111/j.1651-2227.2011.02359.x. [Epub ahead of print]
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哮喘儿童症状预测因素与病情严重恶化预测因素不一致
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比较可疑哮喘患者因乙酰甲胆碱和腺苷的气道高反应性和气道炎症标志物