GERD相关性咳嗽：病理生理学和诊断方法
2011/06/17
摘要
慢性咳嗽是一种常见疾病，常导致患者生活质量显著下降。胃食管反流与咳嗽变异性哮喘和鼻部疾病一起，被认为是咳嗽的三大因素。尽管这样，抑酸治疗的疗效却不尽如人意。本综述旨在分析反流是否能导致咳嗽、何种情况下反流会导致咳嗽以及反流与咳嗽相关性的机制。研究的潜在机制包括咽喉反流、微小吸入和神经元交叉器官致敏。最后，对反流导致的咳嗽的诊断进行分析。
（陈欣 审校）
Curr Gastroenterol Rep. 2011 Apr 5. [Epub ahead of print]
GERD-Related Cough: Pathophysiology and Diagnostic Approach.
Smith JA, Abdulqawi R, Houghton LA.
Respiratory Research Group, University of Manchester, ERC Building, Second Floor, Wythenshawe Hospital, Manchester, M23 9LT, UK, jacky.smith@manchester.ac.uk.
Abstract
Chronic cough is a common problem resulting in significant impairment of quality of life. Along with cough variant asthma and nasal disease, gastroesophageal reflux is considered one of three main causes of cough. Despite this, acid suppression therapy is often far from effective. This review aims to explore whether reflux can lead to cough, the circumstances in which this is most likely to occur, and the potential mechanisms linking these processes. Particular mechanisms to be explored include laryngopharyngeal reflux, microaspiration, and neuronal cross-organ sensitization. Finally, diagnostic approaches are considered.
Curr Gastroenterol Rep. 2011 Apr 5. [Epub ahead of print]
慢性咳嗽是一种常见疾病，常导致患者生活质量显著下降。胃食管反流与咳嗽变异性哮喘和鼻部疾病一起，被认为是咳嗽的三大因素。尽管这样，抑酸治疗的疗效却不尽如人意。本综述旨在分析反流是否能导致咳嗽、何种情况下反流会导致咳嗽以及反流与咳嗽相关性的机制。研究的潜在机制包括咽喉反流、微小吸入和神经元交叉器官致敏。最后，对反流导致的咳嗽的诊断进行分析。
（陈欣 审校）
Curr Gastroenterol Rep. 2011 Apr 5. [Epub ahead of print]
GERD-Related Cough: Pathophysiology and Diagnostic Approach.
Smith JA, Abdulqawi R, Houghton LA.
Respiratory Research Group, University of Manchester, ERC Building, Second Floor, Wythenshawe Hospital, Manchester, M23 9LT, UK, jacky.smith@manchester.ac.uk.
Abstract
Chronic cough is a common problem resulting in significant impairment of quality of life. Along with cough variant asthma and nasal disease, gastroesophageal reflux is considered one of three main causes of cough. Despite this, acid suppression therapy is often far from effective. This review aims to explore whether reflux can lead to cough, the circumstances in which this is most likely to occur, and the potential mechanisms linking these processes. Particular mechanisms to be explored include laryngopharyngeal reflux, microaspiration, and neuronal cross-organ sensitization. Finally, diagnostic approaches are considered.
Curr Gastroenterol Rep. 2011 Apr 5. [Epub ahead of print]
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世界贸易中心消防员咳嗽综合征和可能的PTSD共患病趋势
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中药提取物对瞬时受体电位(TRP)通道的调节作用
