哮喘急性发作的定义
2011/06/17
摘要
综述的目的：过去的10年中，越来越多的研究将哮喘急性发作视为临床研究的主要指标。然而，比较这些结果较为困难，因为不同研究采用的哮喘急性发作定义并不一致。本综述旨在描述采用不同哮喘定义的结果及可能的解决方案。
近期发现：采用不同的哮喘急性发作定义，不仅影响了哮喘急性发作的发生率，而且给哮喘患者的鉴别和风险评估带来了困难。美国胸科学会/欧洲呼吸学会和世界卫生组织基于哮喘的临床症状和治疗分别提出了一致的定义。该定义需要前瞻性定义进行补充，以便更好的为临床哮喘治疗服务。
结论：目前，尚未有普遍接受的哮喘急性发作定义。需要一个哮喘急性发作的前瞻性定义。这可根据临床症状、肺功能参数和其他可能的生物标志物对哮喘急性发作表型进行分类来实现。
（苏楠 审校）
Curr Opin Allergy Clin Immunol. 2011 Apr 5. [Epub ahead of print]
Definitions of asthma exacerbations.
Loymans RJ, Ter Riet G, Sterk PJ.
Department of General Practice, the Netherlands bDepartment of Respiratory Medicine, Academic Medical Centre - University of Amsterdam, Amsterdam, the Netherlands.
Abstract
PURPOSE OF REVIEW: During the past decade exacerbations of asthma have increasingly been recognized a as primary outcome parameter in clinical research. However, comparison of results is hampered by the use of different definitions for asthma exacerbations in published reports. The purpose of this review is to describe the consequences of using different definitions and to propose possible solutions.
RECENT FINDINGS: The use of different definitions of asthma exacerbations not only influences incidence rates, but also affects patient identification and risk assessment. The American Thoracic Society/European Respiratory Society and the World Health Organization independently proposed consensus definitions based on clinical symptoms and management. This needs to be complemented by a prospective definition that may support clinicians in their treatment decisions.
CONCLUSION: Currently there is no commonly accepted definition for asthma exacerbations. A prospective definition is desirable. This could be obtained by phenotyping asthma exacerbations based on clinical signs, lung function parameters and possibly other biomarkers.
Curr Opin Allergy Clin Immunol. 2011 Apr 5. [Epub ahead of print]
综述的目的：过去的10年中，越来越多的研究将哮喘急性发作视为临床研究的主要指标。然而，比较这些结果较为困难，因为不同研究采用的哮喘急性发作定义并不一致。本综述旨在描述采用不同哮喘定义的结果及可能的解决方案。
近期发现：采用不同的哮喘急性发作定义，不仅影响了哮喘急性发作的发生率，而且给哮喘患者的鉴别和风险评估带来了困难。美国胸科学会/欧洲呼吸学会和世界卫生组织基于哮喘的临床症状和治疗分别提出了一致的定义。该定义需要前瞻性定义进行补充，以便更好的为临床哮喘治疗服务。
结论：目前，尚未有普遍接受的哮喘急性发作定义。需要一个哮喘急性发作的前瞻性定义。这可根据临床症状、肺功能参数和其他可能的生物标志物对哮喘急性发作表型进行分类来实现。
（苏楠 审校）
Curr Opin Allergy Clin Immunol. 2011 Apr 5. [Epub ahead of print]
Definitions of asthma exacerbations.
Loymans RJ, Ter Riet G, Sterk PJ.
Department of General Practice, the Netherlands bDepartment of Respiratory Medicine, Academic Medical Centre - University of Amsterdam, Amsterdam, the Netherlands.
Abstract
PURPOSE OF REVIEW: During the past decade exacerbations of asthma have increasingly been recognized a as primary outcome parameter in clinical research. However, comparison of results is hampered by the use of different definitions for asthma exacerbations in published reports. The purpose of this review is to describe the consequences of using different definitions and to propose possible solutions.
RECENT FINDINGS: The use of different definitions of asthma exacerbations not only influences incidence rates, but also affects patient identification and risk assessment. The American Thoracic Society/European Respiratory Society and the World Health Organization independently proposed consensus definitions based on clinical symptoms and management. This needs to be complemented by a prospective definition that may support clinicians in their treatment decisions.
CONCLUSION: Currently there is no commonly accepted definition for asthma exacerbations. A prospective definition is desirable. This could be obtained by phenotyping asthma exacerbations based on clinical signs, lung function parameters and possibly other biomarkers.
Curr Opin Allergy Clin Immunol. 2011 Apr 5. [Epub ahead of print]
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