非过敏性哮喘女童患者抑郁更为常见
2011/06/17
摘要
背景：哮喘能增加儿童共患抑郁症的风险。哮喘或抑郁患儿出现超重的比例较大。本试验旨在研究过敏性和非过敏性哮喘患儿是否更易出现抑郁症，后者的发生与腹部肥胖无关。
方法：对来自于加拿大哮喘、基因和环境研究的数据进行横断面分析。儿科过敏性疾病专家对年龄11～14的儿童进行评价，确定是否存在哮喘、过敏性鼻炎（AR）和过敏性皮炎（AD）。基于皮肤针刺试验结果诊断特应性哮喘，基于除哮喘外是否出现AR或AD诊断过敏性哮喘。采用儿童抑郁量表（简表）对抑郁症状进行评分。基于性别对患者分层，对种族、腰围（WC）和过敏症校正后，采用logistic回归模型分析哮喘患儿出现抑郁的可能。
结果：共计431名11～14岁儿童入选本研究，其中136名哮喘患者和295名非哮喘患者。经协变量校正后，非特应性或非过敏性哮喘女性患者共患抑郁症状的可能性，是健康女童的3倍(OR: 2.84, 95% CI 1.00- 8.10; OR: 3.47, 95% CI 1.30-9.25)。女童腰围每增加10 cm，本研究模型显示发生抑郁症的几率增加39～56%。而在男童，哮喘和腰围均与抑郁无关。
结论：我们推荐所有检查哮喘女童的保健医生及超重的女童，应该严肃对待抑郁症，并及时治疗。
（林江涛 审校）
Chest. 2011 Apr 7. [Epub ahead of print]
DEPRESSION IS MORE COMMON IN GIRLS WITH NON-ATOPIC ASTHMA.
Bahreinian S, Ball GD, Colman I, Becker AB, Kozyrskyj AL.
Dept Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
Abstract
BACKGROUND: Asthma may increase the risk of comorbid depressive disorders in children. Overweight is more prevalent in children suffering from asthma or depression. We examined whether depression was more likely in children with atopic and non-atopic asthma, independent of abdominal adiposity.
METHODS: A cross sectional analysis was performed on data collected in the Study of Asthma, Genes and Environment in Canada. Children at 11-14 years were assessed by a pediatric allergist to confirm asthma, allergic rhinitis (AR) and atopic dermatitis (AD) diagnosis. Atopic asthma was defined based on skin prick testing and allergic asthma based on presence of AR or AD in addition to asthma. Depressive symptoms were assessed using children’s depression inventory - short form. Data were analyzed using logistic regression modeling to determine likelihood of depression in asthmatic children, stratified by gender and adjusting for ethnicity, waist circumference (WC) and atopy.
RESULTS: 431 children at 11-14 years (136 asthmatics and 295 non asthmatics) were studied. After adjusting for the covariates, girls who had non-atopic or non-allergic asthma were 3 times more likely to have comorbid depressive symptoms compared to healthy girls (OR: 2.84, 95% CI 1.00- 8.10; OR: 3.47, 95% CI 1.30-9.25, respectively). For each 10 cm increase in WC of girls there was 39% to 56% increase in chance of depression in our models. In boys, neither asthma nor WC showed an association with depression.
CONCLUSIONS: We recommend all health practitioners who see asthmatic girls or girls who are overweight watch for depressive symptoms and treat comorbid depression seriously.
Chest. 2011 Apr 7. [Epub ahead of print]
背景：哮喘能增加儿童共患抑郁症的风险。哮喘或抑郁患儿出现超重的比例较大。本试验旨在研究过敏性和非过敏性哮喘患儿是否更易出现抑郁症，后者的发生与腹部肥胖无关。
方法：对来自于加拿大哮喘、基因和环境研究的数据进行横断面分析。儿科过敏性疾病专家对年龄11～14的儿童进行评价，确定是否存在哮喘、过敏性鼻炎（AR）和过敏性皮炎（AD）。基于皮肤针刺试验结果诊断特应性哮喘，基于除哮喘外是否出现AR或AD诊断过敏性哮喘。采用儿童抑郁量表（简表）对抑郁症状进行评分。基于性别对患者分层，对种族、腰围（WC）和过敏症校正后，采用logistic回归模型分析哮喘患儿出现抑郁的可能。
结果：共计431名11～14岁儿童入选本研究，其中136名哮喘患者和295名非哮喘患者。经协变量校正后，非特应性或非过敏性哮喘女性患者共患抑郁症状的可能性，是健康女童的3倍(OR: 2.84, 95% CI 1.00- 8.10; OR: 3.47, 95% CI 1.30-9.25)。女童腰围每增加10 cm，本研究模型显示发生抑郁症的几率增加39～56%。而在男童，哮喘和腰围均与抑郁无关。
结论：我们推荐所有检查哮喘女童的保健医生及超重的女童，应该严肃对待抑郁症，并及时治疗。
（林江涛 审校）
Chest. 2011 Apr 7. [Epub ahead of print]
DEPRESSION IS MORE COMMON IN GIRLS WITH NON-ATOPIC ASTHMA.
Bahreinian S, Ball GD, Colman I, Becker AB, Kozyrskyj AL.
Dept Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
Abstract
BACKGROUND: Asthma may increase the risk of comorbid depressive disorders in children. Overweight is more prevalent in children suffering from asthma or depression. We examined whether depression was more likely in children with atopic and non-atopic asthma, independent of abdominal adiposity.
METHODS: A cross sectional analysis was performed on data collected in the Study of Asthma, Genes and Environment in Canada. Children at 11-14 years were assessed by a pediatric allergist to confirm asthma, allergic rhinitis (AR) and atopic dermatitis (AD) diagnosis. Atopic asthma was defined based on skin prick testing and allergic asthma based on presence of AR or AD in addition to asthma. Depressive symptoms were assessed using children’s depression inventory - short form. Data were analyzed using logistic regression modeling to determine likelihood of depression in asthmatic children, stratified by gender and adjusting for ethnicity, waist circumference (WC) and atopy.
RESULTS: 431 children at 11-14 years (136 asthmatics and 295 non asthmatics) were studied. After adjusting for the covariates, girls who had non-atopic or non-allergic asthma were 3 times more likely to have comorbid depressive symptoms compared to healthy girls (OR: 2.84, 95% CI 1.00- 8.10; OR: 3.47, 95% CI 1.30-9.25, respectively). For each 10 cm increase in WC of girls there was 39% to 56% increase in chance of depression in our models. In boys, neither asthma nor WC showed an association with depression.
CONCLUSIONS: We recommend all health practitioners who see asthmatic girls or girls who are overweight watch for depressive symptoms and treat comorbid depression seriously.
Chest. 2011 Apr 7. [Epub ahead of print]
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难治性哮喘患者声带功能异常
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内源性哮喘患者痰液中出现功能性尘螨特异性IgE
