根据遗传学背景预测哮喘病程？
2011/01/27
摘要
临床实践提示我们，哮喘病程随着时间延长，存在较大程度的变化。如果我们能准确预测患者病程，则哮喘患者的治疗将得到相当程度的改善。近期，随着基因组研究时代的到来，我们对遗传因素的理解有了重要变化，强调了哮喘易感性的遗传学因素。研究发现，基因能调节哮喘自然史的诸多方面，如过敏症的易感性、肺的发育变化、对更加严重疾病的易感性。遗传学研究显示，遗传因素参与了哮喘的恢复。然而，虽然发现疾病易感的新的遗传学因素有助于改善我们对疾病致病因素的了解，但是否这些进展能改善哮喘自然病史的预测能力尚存在疑问。此外，将遗传学检测用于临床还有较远的路要走。
（陈欣 审校）
J Allergy Clin Immunol. 2010 Aug;126(2):200-9; quiz 210-1.
Using genetics to predict the natural history of asthma?
Holloway JW, Arshad SH, Holgate ST.
Division of Infection, Inflammation & Immunity, School of Medicine, University of Southampton, Southampton, UK. J.W.Holloway@soton.ac.uk
Abstract
Clinical practice reminds us that there is considerable variability in the course of asthma over time. Treatment of patients with asthma would be considerably improved if one could accurately predict the likely course of disease over the life course. Recently, with the advent of the era of genome-wide association studies, there has been a monumental shift in our understanding of the genetic factors that underlie inherited susceptibility to asthma. Genes have been identified that modulate many aspects of the natural history of asthma, such as susceptibility to atopy, altered lung development, and susceptibility to more severe disease. Heritability studies have even suggested a role for genetic factors in remission of asthma. However, although the discovery of novel genetic factors underlying disease susceptibility has undoubtedly improved our understanding of disease pathogenesis, whether these advances have improved the ability to predict the natural history in individual patients is questionable, and the application of genetic testing to clinical practice remains some way off.
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儿童肥胖与过敏性和非过敏性哮喘间的关系：来自国家健康与营养调查的结果（1999～2006）
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T细胞在哮喘发病中的作用
