变应性致敏作用与鼻病毒，而不是其它病毒诱导的儿童喘息有关
2010/12/31
摘要
背景：目前，有关过敏症与病毒性喘息相关性的数据有限。
目的：在喘息儿童中评价IgE致敏与病毒性感染的相关性。
方法：本试验为一项观察性研究，研究对象为住院的喘息儿童（n = 247；平均年龄1.6岁，四分间距为1.1, 2.9）。采用所有可用方法研究18名呼吸道病毒感染患者。特异性免疫球蛋白IgE致敏（针对食物和空气过敏原）和其它过敏症相关变量（包括总IgE、血液和鼻嗜酸性粒细胞、呼出气一氧化氮、湿疹和过敏性湿疹、父母过敏和哮喘、喘息发作次数、阳性哮喘预测指标、皮质类固醇吸入治疗）与特异性病毒相关。
结果：过敏症与单独鼻病毒感染（n=58）相关，而与合胞体病毒、肠病毒、人博卡病毒和其它病毒、混合病毒感染或无病毒感染未见显著相关性。致敏次数特别与单纯鼻病毒感染相关（经年龄和性别校正后，优势比4.59; 95%CI 1.78, 11.8)，其次为空气过敏原致敏（分别为4.18; 2.00, 8.72）、总IgE水平（2.06; 1.32, 3.21）、食物过敏原（2.02; 1.08, 3.78）、鼻腔嗜酸性粒细胞计数（1.52; 1.08, 2.13）。
结论：我们的结果显示，变应性致敏作用与鼻病毒感染存在正相关，而与其它病毒感染所致的喘息无关，因此，需针对鼻病毒相关性喘息来开展后续研究，并将其作为哮喘发病的一个危险指标。
（刘国梁 审校）
Pediatr Allergy Immunol. 2010 Nov;21(7):1008-14. doi:10.1111/j.1399-3038.2010.01059.x.
Allergic sensitization is associated with rhinovirus-, but not other virus-, induced wheezing in children.
Jartti T, Kuusipalo H, Vuorinen T, Söderlund-Venermo M, Allander T, Waris M, Hartiala J, Ruuskanen O.
Department of Pediatrics, Turku University Hospital, Turku, Finland. tuomas.jartti@utu.fi
Abstract
BACKGROUND: Data on the link between atopy and viral wheeze are limited.
Aim: To evaluate the association between IgE sensitization and viral infection in wheezing children.
METHODS: This is an observational study in hospitalized wheezing children (n = 247; median age 1.6 ; interquartile range 1.1, 2.9). Eighteen respiratory viral infections were studied using all available methods. A specific immunoglobulin E (IgE) sensitization for common food and aeroallergens and other atopy-related variables including total IgE, blood and nasal eosinophils, exhaled nitric oxide, eczema and atopic eczema, parental allergy and asthma, number of wheezing episodes, positive asthma predictive index or asthma and use of inhaled corticosteroid were correlated with specific viral etiology.
RESULTS: Atopy was closely associated with sole rhinovirus etiology (n = 58) but not with sole respiratory syncytial virus, sole enterovirus, sole human bocavirus, sole other virus, mixed viral, or virus negative etiology. The number of sensitizations was particularly associated with sole rhinovirus etiology (odds ratio 4.59; 95% confidence interval 1.78, 11.8; adjusted to age and sex), followed by aeroallergen sensitization (respectively; 4.18; 2.00, 8.72), total IgE level (2.06; 1.32, 3.21), food allergen sensitization (2.02; 1.08, 3.78), and nasal eosinophil count (1.52; 1.08, 2.13).
CONCLUSIONS: According to our data, allergic sensitization is positively linked to rhinovirus-, but not other virus-, associated wheezing and calls attention for studies to test rhinovirus-associated wheezing as a part of asthma risk indices.
Pediatr Allergy Immunol. 2010 Nov;21(7):1008-14. doi: 10.1111/j.1399-3038.2010.01059.x.
背景：目前，有关过敏症与病毒性喘息相关性的数据有限。
目的：在喘息儿童中评价IgE致敏与病毒性感染的相关性。
方法：本试验为一项观察性研究，研究对象为住院的喘息儿童（n = 247；平均年龄1.6岁，四分间距为1.1, 2.9）。采用所有可用方法研究18名呼吸道病毒感染患者。特异性免疫球蛋白IgE致敏（针对食物和空气过敏原）和其它过敏症相关变量（包括总IgE、血液和鼻嗜酸性粒细胞、呼出气一氧化氮、湿疹和过敏性湿疹、父母过敏和哮喘、喘息发作次数、阳性哮喘预测指标、皮质类固醇吸入治疗）与特异性病毒相关。
结果：过敏症与单独鼻病毒感染（n=58）相关，而与合胞体病毒、肠病毒、人博卡病毒和其它病毒、混合病毒感染或无病毒感染未见显著相关性。致敏次数特别与单纯鼻病毒感染相关（经年龄和性别校正后，优势比4.59; 95%CI 1.78, 11.8)，其次为空气过敏原致敏（分别为4.18; 2.00, 8.72）、总IgE水平（2.06; 1.32, 3.21）、食物过敏原（2.02; 1.08, 3.78）、鼻腔嗜酸性粒细胞计数（1.52; 1.08, 2.13）。
结论：我们的结果显示，变应性致敏作用与鼻病毒感染存在正相关，而与其它病毒感染所致的喘息无关，因此，需针对鼻病毒相关性喘息来开展后续研究，并将其作为哮喘发病的一个危险指标。
（刘国梁 审校）
Pediatr Allergy Immunol. 2010 Nov;21(7):1008-14. doi:10.1111/j.1399-3038.2010.01059.x.
Allergic sensitization is associated with rhinovirus-, but not other virus-, induced wheezing in children.
Jartti T, Kuusipalo H, Vuorinen T, Söderlund-Venermo M, Allander T, Waris M, Hartiala J, Ruuskanen O.
Department of Pediatrics, Turku University Hospital, Turku, Finland. tuomas.jartti@utu.fi
Abstract
BACKGROUND: Data on the link between atopy and viral wheeze are limited.
Aim: To evaluate the association between IgE sensitization and viral infection in wheezing children.
METHODS: This is an observational study in hospitalized wheezing children (n = 247; median age 1.6 ; interquartile range 1.1, 2.9). Eighteen respiratory viral infections were studied using all available methods. A specific immunoglobulin E (IgE) sensitization for common food and aeroallergens and other atopy-related variables including total IgE, blood and nasal eosinophils, exhaled nitric oxide, eczema and atopic eczema, parental allergy and asthma, number of wheezing episodes, positive asthma predictive index or asthma and use of inhaled corticosteroid were correlated with specific viral etiology.
RESULTS: Atopy was closely associated with sole rhinovirus etiology (n = 58) but not with sole respiratory syncytial virus, sole enterovirus, sole human bocavirus, sole other virus, mixed viral, or virus negative etiology. The number of sensitizations was particularly associated with sole rhinovirus etiology (odds ratio 4.59; 95% confidence interval 1.78, 11.8; adjusted to age and sex), followed by aeroallergen sensitization (respectively; 4.18; 2.00, 8.72), total IgE level (2.06; 1.32, 3.21), food allergen sensitization (2.02; 1.08, 3.78), and nasal eosinophil count (1.52; 1.08, 2.13).
CONCLUSIONS: According to our data, allergic sensitization is positively linked to rhinovirus-, but not other virus-, associated wheezing and calls attention for studies to test rhinovirus-associated wheezing as a part of asthma risk indices.
Pediatr Allergy Immunol. 2010 Nov;21(7):1008-14. doi: 10.1111/j.1399-3038.2010.01059.x.
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早期和晚期对乙酰氨基酚暴露对哮喘和过敏症的影响：出生队列研究
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慢性哮喘患者单次吸入孟鲁司特的I期临床试验：随机、安慰剂对照、剂量探索性研究
