支气管哮喘治疗后患者认知功能的改善
2010/12/17
摘要
背景：由于漏诊和治疗不足，老年患者的哮喘严重程度常常被低估。其原因是多方面的。在老年患者中，许多慢性疾病都可能导致认知功能下降，从而影响了诊断和治疗。本试验旨在评价适当的哮喘治疗对认知功能的影响。
方法：诊断为支气管哮喘的359患者参与本试验，其中包括219名女性和140名男性，平均年龄为69±4.03岁。在治疗开始时及1年后，采用简易智力状态检查（MMSE）检测认知功能。基于患者初始MMSE评分，将患者分为3组：痴呆组、轻度认知障碍（MCI）组及认知良好组。
结果：在研究初始时，31.2%的患者存在未控制性哮喘，46.2%表现为哮喘部分控制，25.1%哮喘得到控制。在整个治疗过程中，哮喘控制得到显著改善。治疗1年后的平均MMSE评分在痴呆患者中显著增加（18.2±3.1至21.9±2.1；P<0.01），在MCI组患者，MMSE评分从25.4±0.9增加至27.2±1.2，在认知较好患者中，MMSE评分从27.4±0.7增加至29.7±0.4（卡方检验：P>0.01）。
结论：对认知功能受损的哮喘患者，适当的哮喘控制能改善某些认知功能。
（林江涛 审校）
J Asthma. 2010 Sep 27. [Epub ahead of print]
The improvement of cognitive functions in patients with bronchial asthma after therapy.
Bozek A, Krajewska J, Jarzab J.
Clinical Department of Internal Medicine, Dermatology and Allergology, Silesian University School of Medicine, Zabrze, Poland.
Abstract
Background. The severity of asthma in older people is frequently underestimated because of underdiagnosis and undertreatment. There are a number of reasons for this. In elderly patients, chronic diseases can be related to declining cognitive function. This situation could influence diagnosis and treatment. The objective of this study was to evaluate the influence of appropriate asthma therapy on cognitive function. Methods. A total of 359 participants diagnosed with bronchial asthma, 219 women and 140 men with a mean age of 69±4.03 years, were included in this study. Cognitive function was assessed with the Mini-Mental State Examination (MMSE) at the beginning of this study and after 1 year. Patients were divided into three subgroups based on their initial MMSE scores dementia, mild cognitive impairment (MCI), and good cognition. Results. At the beginning of this study, 31.2% of patients presented uncontrolled asthma, 46.2% exhibited partly controlled asthma, and 25.1% had well-controlled asthma. A significant improvement in control over the patients’ asthma was observed over the course of this study. After 1 year of treatment, the mean MMSE score significantly increased in initially demented patients, from 18.2±3.1 (mean±SD) to 21.9±2.1 (p < .01); in subjects with MCI, from 25.4±0.9 to 27.2±1.2; and in patients with good cognition, from 27.4±0.7 to 29.7±0.4 (chi-square test, p < .01). Conclusion. Proper control of asthma in patients with cognitive impairments can improve some cognitive functions.
J Asthma. 2010 Sep 27. [Epub ahead of print]
背景：由于漏诊和治疗不足，老年患者的哮喘严重程度常常被低估。其原因是多方面的。在老年患者中，许多慢性疾病都可能导致认知功能下降，从而影响了诊断和治疗。本试验旨在评价适当的哮喘治疗对认知功能的影响。
方法：诊断为支气管哮喘的359患者参与本试验，其中包括219名女性和140名男性，平均年龄为69±4.03岁。在治疗开始时及1年后，采用简易智力状态检查（MMSE）检测认知功能。基于患者初始MMSE评分，将患者分为3组：痴呆组、轻度认知障碍（MCI）组及认知良好组。
结果：在研究初始时，31.2%的患者存在未控制性哮喘，46.2%表现为哮喘部分控制，25.1%哮喘得到控制。在整个治疗过程中，哮喘控制得到显著改善。治疗1年后的平均MMSE评分在痴呆患者中显著增加（18.2±3.1至21.9±2.1；P<0.01），在MCI组患者，MMSE评分从25.4±0.9增加至27.2±1.2，在认知较好患者中，MMSE评分从27.4±0.7增加至29.7±0.4（卡方检验：P>0.01）。
结论：对认知功能受损的哮喘患者，适当的哮喘控制能改善某些认知功能。
（林江涛 审校）
J Asthma. 2010 Sep 27. [Epub ahead of print]
The improvement of cognitive functions in patients with bronchial asthma after therapy.
Bozek A, Krajewska J, Jarzab J.
Clinical Department of Internal Medicine, Dermatology and Allergology, Silesian University School of Medicine, Zabrze, Poland.
Abstract
Background. The severity of asthma in older people is frequently underestimated because of underdiagnosis and undertreatment. There are a number of reasons for this. In elderly patients, chronic diseases can be related to declining cognitive function. This situation could influence diagnosis and treatment. The objective of this study was to evaluate the influence of appropriate asthma therapy on cognitive function. Methods. A total of 359 participants diagnosed with bronchial asthma, 219 women and 140 men with a mean age of 69±4.03 years, were included in this study. Cognitive function was assessed with the Mini-Mental State Examination (MMSE) at the beginning of this study and after 1 year. Patients were divided into three subgroups based on their initial MMSE scores dementia, mild cognitive impairment (MCI), and good cognition. Results. At the beginning of this study, 31.2% of patients presented uncontrolled asthma, 46.2% exhibited partly controlled asthma, and 25.1% had well-controlled asthma. A significant improvement in control over the patients’ asthma was observed over the course of this study. After 1 year of treatment, the mean MMSE score significantly increased in initially demented patients, from 18.2±3.1 (mean±SD) to 21.9±2.1 (p < .01); in subjects with MCI, from 25.4±0.9 to 27.2±1.2; and in patients with good cognition, from 27.4±0.7 to 29.7±0.4 (chi-square test, p < .01). Conclusion. Proper control of asthma in patients with cognitive impairments can improve some cognitive functions.
J Asthma. 2010 Sep 27. [Epub ahead of print]
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