圣文森特与格林纳丁斯的哮喘人群特征：哮喘严重程度与过敏
2010/11/03
摘要
背景：据报道，1986～2002年，发展中国家-圣文森特与格林纳丁斯（SVG）哮喘的发病率增加了4.5倍。目前，对于空气过敏原在SVG的哮喘发生中是否产生了重要作用尚不清楚。
目的：本研究旨在成人中探究空气性过敏原在哮喘发生中的重要性及年龄与哮喘持续之间的关系。
方法：患者来自于该国的哮喘门诊。525名患者诊断为哮喘，基于国家心肺及血液研究标准对哮喘严重程度分级。参与者分为3个年龄组【≤6 岁（n=176），7～18岁（n=164）和≥19岁（n=185）】，其中171名患者进行皮肤针刺试验，检测屋尘螨、猫抗原、狗抗原、蟑螂抗原、花粉及霉菌等。同时记录哮喘发作年龄。
结果：235名（44.8%）患者诊断为持续性哮喘，并且随着年龄增加而增加（p<0.0001）。171名患者中，有121名（70.8%）诊断为过敏症，而且在持续性哮喘患者中过敏症患者比例显著增加（p<0.004）。对于间歇性哮喘患者，过敏症与年龄相关，但该相关性未在持续性哮喘患者中观察到。过敏症患者最常见的过敏原是屋尘螨（93.4%），其次是蟑螂抗原（47.9%）。成人期发作的哮喘患者，其过敏症发生率较18岁以前出现哮喘的患者显著下降（p<0.05）。
结论：SVG哮喘人群中，哮喘与过敏症的同时存在，表明过敏症可能是导致哮喘患者人数突增的原因。SVG地区哮喘特征以及持续哮喘发生率随年龄而增加，与以前发达国家的特征类似。
（苏楠 审校）
J Asthma. 2010 Sep 17. [Epub ahead of print]
Characterization of the asthmatic population of St. Vincent and the Grenadines: Asthma severity levels and atopic sensitization.
Schwindt CD, Bacchus H, Leu SY, Tjoa T, Klebanova Y, Delfino RJ.
School of Medicine, Department of Pediatrics, University of California, Irvine, CA, USA.
Abstract
Background.The developing country of St. Vincent and the Grenadines (SVG) reported a 4.5-fold increase in wheezing incidence between 1986 and 2002. It is unknown whether aeroallergens play a significant role in asthma in SVG.
Objective. The objective of the study is to investigate the importance of aeroallergens and the association between age and persistence of asthma into adulthood.
Methods. Subjects were recruited from the National Asthma Clinic. Asthma was diagnosed in 525 participants and severity levels assigned according to the National Heart, Lung, and Blood Institute guidelines. Participants were separated into three age groups [≤6 years (n=176), 7-18 years (n=164), and ≥19 years (n=185)]. Skin testing was performed on 171 participants to dust mite, cat, dog, cockroach, pollens, and mold. Age of asthma onset was obtained.
Results. Persistent asthma was diagnosed in 235 participants (44.8%) and increased with increasing age group (p<.0001). Atopy was identified in 121/171 (70.8%) participants and was significantly higher in persistent asthma (p<.004). A significant positive association was seen between atopy and age group (p<.0004) in participants with intermittent asthma but not in participants with persistent asthma. The most common allergen among the atopic participants was house dust mite (93.4%), followed by cockroach (47.9%). Adult participants reporting asthma onset in adulthood were less atopic than those whose asthma developed ≤18 years of age (p<.05).
Conclusions. The predominance of asthma with atopy in SVG implicates a role for atopy in the sudden rise in asthma cases. This asthma characteristic and the increase in persistent asthma with age in SVG are similar to those reported in the developed countries.
J Asthma. 2010 Sep 17. [Epub ahead of print]
背景：据报道，1986～2002年，发展中国家-圣文森特与格林纳丁斯（SVG）哮喘的发病率增加了4.5倍。目前，对于空气过敏原在SVG的哮喘发生中是否产生了重要作用尚不清楚。
目的：本研究旨在成人中探究空气性过敏原在哮喘发生中的重要性及年龄与哮喘持续之间的关系。
方法：患者来自于该国的哮喘门诊。525名患者诊断为哮喘，基于国家心肺及血液研究标准对哮喘严重程度分级。参与者分为3个年龄组【≤6 岁（n=176），7～18岁（n=164）和≥19岁（n=185）】，其中171名患者进行皮肤针刺试验，检测屋尘螨、猫抗原、狗抗原、蟑螂抗原、花粉及霉菌等。同时记录哮喘发作年龄。
结果：235名（44.8%）患者诊断为持续性哮喘，并且随着年龄增加而增加（p<0.0001）。171名患者中，有121名（70.8%）诊断为过敏症，而且在持续性哮喘患者中过敏症患者比例显著增加（p<0.004）。对于间歇性哮喘患者，过敏症与年龄相关，但该相关性未在持续性哮喘患者中观察到。过敏症患者最常见的过敏原是屋尘螨（93.4%），其次是蟑螂抗原（47.9%）。成人期发作的哮喘患者，其过敏症发生率较18岁以前出现哮喘的患者显著下降（p<0.05）。
结论：SVG哮喘人群中，哮喘与过敏症的同时存在，表明过敏症可能是导致哮喘患者人数突增的原因。SVG地区哮喘特征以及持续哮喘发生率随年龄而增加，与以前发达国家的特征类似。
（苏楠 审校）
J Asthma. 2010 Sep 17. [Epub ahead of print]
Characterization of the asthmatic population of St. Vincent and the Grenadines: Asthma severity levels and atopic sensitization.
Schwindt CD, Bacchus H, Leu SY, Tjoa T, Klebanova Y, Delfino RJ.
School of Medicine, Department of Pediatrics, University of California, Irvine, CA, USA.
Abstract
Background.The developing country of St. Vincent and the Grenadines (SVG) reported a 4.5-fold increase in wheezing incidence between 1986 and 2002. It is unknown whether aeroallergens play a significant role in asthma in SVG.
Objective. The objective of the study is to investigate the importance of aeroallergens and the association between age and persistence of asthma into adulthood.
Methods. Subjects were recruited from the National Asthma Clinic. Asthma was diagnosed in 525 participants and severity levels assigned according to the National Heart, Lung, and Blood Institute guidelines. Participants were separated into three age groups [≤6 years (n=176), 7-18 years (n=164), and ≥19 years (n=185)]. Skin testing was performed on 171 participants to dust mite, cat, dog, cockroach, pollens, and mold. Age of asthma onset was obtained.
Results. Persistent asthma was diagnosed in 235 participants (44.8%) and increased with increasing age group (p<.0001). Atopy was identified in 121/171 (70.8%) participants and was significantly higher in persistent asthma (p<.004). A significant positive association was seen between atopy and age group (p<.0004) in participants with intermittent asthma but not in participants with persistent asthma. The most common allergen among the atopic participants was house dust mite (93.4%), followed by cockroach (47.9%). Adult participants reporting asthma onset in adulthood were less atopic than those whose asthma developed ≤18 years of age (p<.05).
Conclusions. The predominance of asthma with atopy in SVG implicates a role for atopy in the sudden rise in asthma cases. This asthma characteristic and the increase in persistent asthma with age in SVG are similar to those reported in the developed countries.
J Asthma. 2010 Sep 17. [Epub ahead of print]
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普通人群哮喘症状及诊断：来自SHIP数据库的纵向研究结果
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瑞典一项针对老年人的队列研究中死亡率、哮喘与健康相关生活质量的关系
