支气管反应性增加少年儿童体力活动下降
2010/08/11
摘要
背景： 体力活动对于少年儿童的正常发育及维持生活质量必不可少。对于存在亚临床哮喘的患儿，其体力活动也相应减少。因此，有必要检测亚临床哮喘少年患儿的体力活动下降程度。
目的：研究学龄前儿童的体力活动与哮喘客观表型之间的相关性。方法：对来自哥本哈根哮喘儿童前瞻性研究的253名5岁儿童（127名女性）进行研究。将加速仪绑在踝关节，连续4周客观检测体力活动水平；哮喘客观表型通过支气管舒张剂使用前后的特异性气道阻力、支气管对干燥空气过度通气的反应性以及呼出气一氧化氮水平来评价。采用主成分分析及广义线性模型进行分析。
结果：体力活动与支气管反应性成负相关(RR, 0.89; 95% CI, 0.83-0.95; P = .007)，而且体力活动在春天和夏天(P < .001)以及男性儿童(RR, 1.16; 95% CI, 1.09-1.25; P < .001)中增加。体力活动与哮喘诊断、年龄、体重指数、基线状态下的特异性气道阻力、β受体激动剂的可逆性、敏感性及呼出气一氧化氮水平无关。
结论：学龄前儿童的体力活动随着支气管反应性增加而下降。体力活动下降处于亚临床状态，尽管出生后儿童与父母每天在一起，并且有临床医生进行密切随访，但体力活动下降这一问题仍然可能被忽视。我们的研究显示，临床上有必要意识到这些极为轻度的哮喘症状。
（苏楠 审校）
J Allergy Clin Immunol. 2010 May;125(5):1007-12. Epub 2010 Apr 14.
Physical activity in young children is reduced with increasing bronchial responsiveness.
Brasholt M, Baty F, Bisgaard H.
Copenhagen Prospective Studies on Asthma in Childhood; the Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen; and Copenhagen University Hospital, Gentofte, Copenhagen, Denmark.
Abstract
BACKGROUND: Physical activity is essential for young children to develop adequately and for quality of life. It can be lower in children with subclinical asthma, and therefore methods to reveal subclinical reduction in physical activity in young children are warranted.
OBJECTIVE: We sought to study an association between physical activity in preschool children and objectively assessed intermediary asthma phenotypes.
METHODS: We studied 253 five-year-old children (127 girls) participating in the Copenhagen Prospective Studies on Asthma in Childhood. The main outcome measure was level of physical activity assessed objectively with accelerometers worn on an ankle for 4 weeks. Objective assessment of asthma intermediary phenotypes included prebronchodilator and postbronchodilator specific airway resistance, bronchial responsiveness to cold dry-air hyperventilation, and exhaled nitric oxide levels. Analyses were performed with generalized linear model and principal component analysis.
RESULTS: Physical activity was inversely associated with bronchial responsiveness (relative rate, 0.89; 95% CI, 0.83-0.95; P = .007) and significantly increased in the months of spring and summer (P < .001) and in boys (relative rate, 1.16; 95% CI, 1.09-1.25; P < .001). Physical activity was independent of asthma diagnosis, age, body mass index, baseline specific airway resistance, reversibility to beta(2)-agonist, sensitization, and exhaled nitric oxide level.
CONCLUSION: Physical activity in preschool children was reduced with increasing bronchial responsiveness. The reduced physical activity was subclinical and not realized by parents or doctors despite daily diary cards and close clinical follow-up since birth. This observation warrants awareness of even very mild asthma symptoms in clinical practice
J Allergy Clin Immunol. 2010 May;125(5):1007-12. Epub 2010 Apr 1
背景： 体力活动对于少年儿童的正常发育及维持生活质量必不可少。对于存在亚临床哮喘的患儿，其体力活动也相应减少。因此，有必要检测亚临床哮喘少年患儿的体力活动下降程度。
目的：研究学龄前儿童的体力活动与哮喘客观表型之间的相关性。方法：对来自哥本哈根哮喘儿童前瞻性研究的253名5岁儿童（127名女性）进行研究。将加速仪绑在踝关节，连续4周客观检测体力活动水平；哮喘客观表型通过支气管舒张剂使用前后的特异性气道阻力、支气管对干燥空气过度通气的反应性以及呼出气一氧化氮水平来评价。采用主成分分析及广义线性模型进行分析。
结果：体力活动与支气管反应性成负相关(RR, 0.89; 95% CI, 0.83-0.95; P = .007)，而且体力活动在春天和夏天(P < .001)以及男性儿童(RR, 1.16; 95% CI, 1.09-1.25; P < .001)中增加。体力活动与哮喘诊断、年龄、体重指数、基线状态下的特异性气道阻力、β受体激动剂的可逆性、敏感性及呼出气一氧化氮水平无关。
结论：学龄前儿童的体力活动随着支气管反应性增加而下降。体力活动下降处于亚临床状态，尽管出生后儿童与父母每天在一起，并且有临床医生进行密切随访，但体力活动下降这一问题仍然可能被忽视。我们的研究显示，临床上有必要意识到这些极为轻度的哮喘症状。
（苏楠 审校）
J Allergy Clin Immunol. 2010 May;125(5):1007-12. Epub 2010 Apr 14.
Physical activity in young children is reduced with increasing bronchial responsiveness.
Brasholt M, Baty F, Bisgaard H.
Copenhagen Prospective Studies on Asthma in Childhood; the Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen; and Copenhagen University Hospital, Gentofte, Copenhagen, Denmark.
Abstract
BACKGROUND: Physical activity is essential for young children to develop adequately and for quality of life. It can be lower in children with subclinical asthma, and therefore methods to reveal subclinical reduction in physical activity in young children are warranted.
OBJECTIVE: We sought to study an association between physical activity in preschool children and objectively assessed intermediary asthma phenotypes.
METHODS: We studied 253 five-year-old children (127 girls) participating in the Copenhagen Prospective Studies on Asthma in Childhood. The main outcome measure was level of physical activity assessed objectively with accelerometers worn on an ankle for 4 weeks. Objective assessment of asthma intermediary phenotypes included prebronchodilator and postbronchodilator specific airway resistance, bronchial responsiveness to cold dry-air hyperventilation, and exhaled nitric oxide levels. Analyses were performed with generalized linear model and principal component analysis.
RESULTS: Physical activity was inversely associated with bronchial responsiveness (relative rate, 0.89; 95% CI, 0.83-0.95; P = .007) and significantly increased in the months of spring and summer (P < .001) and in boys (relative rate, 1.16; 95% CI, 1.09-1.25; P < .001). Physical activity was independent of asthma diagnosis, age, body mass index, baseline specific airway resistance, reversibility to beta(2)-agonist, sensitization, and exhaled nitric oxide level.
CONCLUSION: Physical activity in preschool children was reduced with increasing bronchial responsiveness. The reduced physical activity was subclinical and not realized by parents or doctors despite daily diary cards and close clinical follow-up since birth. This observation warrants awareness of even very mild asthma symptoms in clinical practice
J Allergy Clin Immunol. 2010 May;125(5):1007-12. Epub 2010 Apr 1
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