调节白介素17水平：一项有吸引力的哮喘治疗方法
2010/08/11
白介素17可以通过调节许多炎症介质，包括细胞因子、趋化因子和粘附因子，在诸多免疫和炎症反应中起到了重要作用。越来越多的研究显示，白介素17参与了哮喘的发病过程。白介素17参与了哮喘中性粒细胞向气道的浸润和Th2细胞介导的嗜酸性气道炎症。近期研究显示，除了抑制白介素17，调节白介素17表达的调节因子也能够抑制哮喘动物模型中抗原诱导的气道炎症、支气管高反应性以及Th2细胞因子水平。本文主要综述白介素17在过敏性气道炎症中的作用，以及讨论针对白介素17的策略在哮喘治疗中的作用。
（陈欣 审校）
Respir Res. 2010 Jun 16;11(1):78. [Epub ahead of print]
Interleukin-17 regulation: an attractive therapeutic approach for asthma.
Park SJ, Lee YC.
Abstract
Interleukin (IL)-17 is recognized to play a critical role in numerous immune and inflammatory responses by regulating the expression of various inflammatory mediators, which include cytokines, chemokines, and adhesion molecules. There is growing evidence that IL-17 is involved in the pathogenesis of asthma. IL-17 orchestrates the neutrophilic influx into the airways and also enhances T-helper 2 (Th2) cell-mediated eosinophilic airway inflammation in asthma. Recent studies have demonstrated that not only inhibitor of IL-17 per se but also diverse regulators of IL-17 expression reduce antigen-induced airway inflammation, bronchial hyperresponsiveness, and Th2 cytokine levels in animal models of asthma. This review will summarize the role of IL-17 in the context of allergic airway inflammation and discuss the therapeutic potential of various strategies targeting IL-17 for asthma.
Respir Res. 2010 Jun 16;11(1):78. [Epub ahead of print]
（陈欣 审校）
Respir Res. 2010 Jun 16;11(1):78. [Epub ahead of print]
Interleukin-17 regulation: an attractive therapeutic approach for asthma.
Park SJ, Lee YC.
Abstract
Interleukin (IL)-17 is recognized to play a critical role in numerous immune and inflammatory responses by regulating the expression of various inflammatory mediators, which include cytokines, chemokines, and adhesion molecules. There is growing evidence that IL-17 is involved in the pathogenesis of asthma. IL-17 orchestrates the neutrophilic influx into the airways and also enhances T-helper 2 (Th2) cell-mediated eosinophilic airway inflammation in asthma. Recent studies have demonstrated that not only inhibitor of IL-17 per se but also diverse regulators of IL-17 expression reduce antigen-induced airway inflammation, bronchial hyperresponsiveness, and Th2 cytokine levels in animal models of asthma. This review will summarize the role of IL-17 in the context of allergic airway inflammation and discuss the therapeutic potential of various strategies targeting IL-17 for asthma.
Respir Res. 2010 Jun 16;11(1):78. [Epub ahead of print]
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重症哮喘时p38 MAPK对激素抑制细胞因子释放的抑制作用
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转化生长因子β1在气道平滑肌扩张中的作用：是否需要成纤维细胞生长因子-2
